ArticleeLife2015
The asymmetry of female meiosis reduces the frequency of inheritance of unpaired chromosomes.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- An egg-sabotaging mechanism drives non-Mendelian transmission in mice.Current biology : CB · 2024Article
- Non-Mendelian transmission of X chromosomes: mechanisms and impact on sex ratios and population dynamics in different breeding systems.Biochemical Society transactions · 2024Review
- Article
- The Rac1 homolog CED-10 is a component of the MES-1/SRC-1 pathway for asymmetric division of thebioRxiv : the preprint server for biology · 2024Article
- An egg sabotaging mechanism drives non-Mendelian transmission in mice.bioRxiv : the preprint server for biology · 2024Article
- An Emerging Animal Model for Querying the Role of Whole Genome Duplication in Development, Evolution, and Disease.Journal of developmental biology · 2023Review
- Article
- Formation of artificial chromosomes in Caenorhabditis elegans and analyses of their segregation in mitosis, DNA sequence composition and holocentromere organization.Nucleic acids research · 2021Article
- Unravelling the mystery of female meiotic drive: where we are.Open biology · 2021Review
- Fisher vs. the Worms: Extraordinary Sex Ratios in Nematodes and the Mechanisms that Produce Them.Cells · 2021Review
- Evidence for anaphase pulling forces during C. elegans meiosis.The Journal of cell biology · 2020Article
- Excess crossovers impede faithful meiotic chromosome segregation in C. elegans.PLoS genetics · 2020Article
- Article
- Incomplete Sterility of Chromosomal Hybrids: Implications for Karyotype Evolution and Homoploid Hybrid Speciation.Frontiers in genetics · 2020Article
- Versatility of multivalent orientation, inverted meiosis, and rescued fitness in holocentric chromosomal hybrids.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Multiple Aspects of PIP2 Involvement inInternational journal of molecular sciences · 2018Article
- Condensin I protects meiotic cohesin from WAPL-1 mediated removal.PLoS genetics · 2018Article
- Manipulation of Ploidy in Caenorhabditis elegans.Journal of visualized experiments : JoVE · 2018Article
- Sex- and Gamete-Specific Patterns of X Chromosome Segregation in a Trioecious Nematode.Current biology : CB · 2018Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Trisomy, the presence of a third copy of one chromosome, is deleterious and results in inviable or defective progeny if passed through the germ line. Random segregation of an extra chromosome is predicted to result in a high frequency of trisomic offspring from a trisomic parent. Caenorhabditis elegans with trisomy of the X chromosome, however, have far fewer trisomic offspring than expected. We found that the extra X chromosome was preferentially eliminated during anaphase I of female meiosis. We utilized a mutant with a specific defect in pairing of the X chromosome as a model to investigate the apparent bias against univalent inheritance. First, univalents lagged during anaphase I and their movement was biased toward the cortex and future polar body. Second, late-lagging univalents were frequently captured by the ingressing polar body contractile ring. The asymmetry of female meiosis can thus partially correct pre-existing trisomy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.