ReviewWorld journal of hepatology2015
Cirrhosis in children and adolescents: An overview.
Review in World journal of hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.
- Changing etiological spectrum of cirrhosis in China: a systematic review and meta-analysis.BMC gastroenterology · 2026Pooled it
- Impact of bacterial infection on native liver survival in children with cirrhosis due to biliary atresia.Clinical and experimental pediatrics · 2026Article
- Physiological and Anatomical Alterations in Children with Liver Cirrhosis.Pharmaceutical research · 2026Review
- Evaluation of miRNA Expression in Pediatric Cirrhosis Caused by BA and PFIC.BioMed research international · 2026Article
- Pretransplant mortality in children awaiting living donor liver transplantation: a prospective center-based study.World journal of pediatric surgery · 2026Article
- FOCAD Gene Defect Resulting in Rapidly Progressing Neonatal Liver Cirrhosis Requiring Transplant.Cureus · 2025Article
- Predictors of health-seeking behavior in patients with chronic liver disease and a comparison of health-seeking based on patient-type.BMC gastroenterology · 2025Article
- Childhood liver cirrhosis in a resource-limited area: A case report.International journal of surgery case reports · 2025Article
- Primary and Secondary Prophylaxis of Gastrointestinal Bleeding in Children with Portal Hypertension: A Multicenter National Study by SIGENP.Children (Basel, Switzerland) · 2025Article
- Expansion of CD103Frontiers in immunology · 2025Article
- Value of preoperative APRI and FIB-4 in assessing short-term prognosis after Kasai portoenterostomy.World journal of pediatric surgery · 2025Article
- Liver fibrosis pathologies and potentials of RNA based therapeutics modalities.Drug delivery and translational research · 2024Review
- Evaluating the Association between Anemia and the Severity of Liver Disease in Children with Cirrhosis: A Cross-Sectional Study from 2015 to 2020.Pediatric gastroenterology, hepatology & nutrition · 2024Article
- Non-Invasive Assessment of Metabolic Dysfunction-Associated Steatotic Liver Disease in Adolescents with Severe Obesity; Patient Characteristics and Association with Leptin-A Cross-Sectional Overview of Baseline Data from a RCT.Children (Basel, Switzerland) · 2024Article
- Pediatric Perspectives on Liver Cirrhosis: Unravelling Clinical Patterns and Therapeutic Challenges.Journal of clinical medicine · 2024Review
- Hepatic Encephalopathy in Children.Indian journal of pediatrics · 2024Review
- Technical optimization of spatially resolved single-cell transcriptomic datasets to study clinical liver disease.Scientific reports · 2024Article
- Age-specific causes of upper gastrointestinal bleeding in children.World journal of gastroenterology · 2023Review
- Cost-effectiveness analysis of liver transplantation in biliary atresia according to the severity of end-stage liver disease.BMC pediatrics · 2023Article
- Liver cirrhosis in children - the role of imaging in the diagnostic pathway.Pediatric radiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several conditions, especially chronic liver diseases, can lead to cirrhosis in children and adolescents. Most cases in clinical practice are caused by similar etiologies. In infants, cirrhosis is most often caused by biliary atresia and genetic-metabolic diseases, while in older children, it tends to result from autoimmune hepatitis, Wilson's disease, alpha-1-antitrypsin deficiency and primary sclerosing cholangitis. The symptoms of cirrhosis in children and adolescents are similar to those of adults. However, in pediatric patients, the first sign of cirrhosis is often poor weight gain. The complications of pediatric cirrhosis are similar to those observed in adult patients, and include gastrointestinal bleeding caused by gastroesophageal varices, ascites and spontaneous bacterial peritonitis. In pediatric patients, special attention should be paid to the nutritional alterations caused by cirrhosis, since children and adolescents have higher nutritional requirements for growth and development. Children and adolescents with chronic cholestasis are at risk for several nutritional deficiencies. Malnutrition can have severe consequences for both pre- and post-liver transplant patients. The treatment of cirrhosis-induced portal hypertension in children and adolescents is mostly based on methods developed for adults. The present article will review the diagnostic and differential diagnostic aspects of end-stage liver disease in children, as well as the major treatment options for this condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.