ArticleOncoTargets and therapy2015
Clinical significance of ALDH2 rs671 polymorphism in esophageal cancer: evidence from 31 case-control studies.
Article in OncoTargets and therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Cumulative evidence for association between genetic polymorphisms and esophageal cancer susceptibility: A review with evidence from meta-analysis and genome-wide association studies.Cancer medicine · 2019Pooled it
- The Effects of Personalized Feedback About ALDH2*2, Alcohol Use, and Associated Health Risks on Drinking Intention and Consumption: The Role of Self-Efficacy and Perceived Threat.Alcohol, clinical & experimental research · 2026Trial
- Review
- Non-Acid Fluid Exposure and Esophageal Squamous Cell Carcinoma.Digestive diseases and sciences · 2022Review
- Alcohol metabolism genes and risks of site-specific cancers in Chinese adults: An 11-year prospective study.International journal of cancer · 2022Article
- The Aldehyde Dehydrogenase ALDH2*2 Allele, Associated with Alcohol Drinking Behavior, Dates Back to Prehistoric Times.Biomolecules · 2021Article
- Risk factors for esophageal iodine-unstained lesions and changing trends among Japanese alcohol-dependent men (2003-2018).Cancer science · 2021Article
- Article
- Risk Factors and Genetic Biomarkers of Multiple Primary Cancers in Esophageal Cancer Patients.Frontiers in oncology · 2020Article
- Genetic determinants of beverage consumption: Implications for nutrition and health.Advances in food and nutrition research · 2019Review
- Endoscopic screening using esophageal iodine staining and genotypes of ADH1B and ALDH2 in Japanese alcohol-dependent women.PloS one · 2019Article
- Association of low-activity ALDH2 and alcohol consumption with risk of esophageal cancer in Chinese adults: A population-based cohort study.International journal of cancer · 2018Article
- Human Genetics of Addiction: New Insights and Future Directions.Current psychiatry reports · 2018Review
- ALDH2 polymorphism and alcohol-related cancers in Asians: a public health perspective.Journal of biomedical science · 2017Review
- Association of genetic polymorphisms with laryngeal carcinoma prognosis in a Chinese population.Oncotarget · 2017Article
- Association of genotypes of rs671 withinCancer biology & medicine · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAldehyde dehydrogenase 2 (ALDH2), a critical enzyme for the detoxification of alcohol, is associated with many types of cancers. To verify the relationship of ALDH2 rs671 G>A polymorphism and esophageal cancer (EC), we performed a meta-analysis of a total of 31 published data including 8,510 patients and 16,197 controls.
methodsThe pooled odds ratio (OR) and the 95% confidence interval (CI) were calculated using a fixed or random-effects model. Heterogeneity (PH ), publication bias, and sensitivity analysis were also determined.
resultsAlthough a protective effort was found in the rs671 homozygote comparison (AA/GG: OR=0.69; 95% CI=0.48-0.98), the heterozygote comparison was apparently associated with the risk of EC, particularly in the Chinese population ( AG/GG: OR=1.39; 95% CI=1.03-1.87). Alcohol consumption remarkably increased this risk, especially in the AG genotype. Drinking men with the AG genotype appeared to show a higher risk ( AG/GG: OR=4.39; 95% CI=1.24-6.55) than drinking women.
conclusionThe present meta-analysis provided advanced information regarding the association of the ALDH2 A>G polymorphism and EC. Taken together, insights from this study suggested an enhanced effect on the development of EC through a genetic-environmental interaction.
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