ArticleNeuropsychiatric disease and treatment2015
Effects of prolonged head-down bed rest on working memory.
Article in Neuropsychiatric disease and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- The acute, systemic effects of aerobic exercise in recently concussed adolescent student-athletes: preliminary findings.European journal of applied physiology · 2022Trial
- Review
- Effects of seasonal factors on brain function: Systematic review and future perspectives.iScience · 2025Article
- Behavioral and multiomics analysis of 3D clinostat simulated microgravity effect in mice focusing on the central nervous system.Scientific reports · 2025Article
- Cognition in zero gravity: Effects of non-terrestrial gravity on human behaviour.Quarterly journal of experimental psychology (2006) · 2023Article
- Review
- Individual Variation Exists Within the Psychological Response to Hypoxic Bed Rest: A Retrospective Analysis.Frontiers in physiology · 2022Article
- Dammarane Sapogenins Improving Simulated Weightlessness-Induced Depressive-Like Behaviors and Cognitive Dysfunction in Rats.Frontiers in psychiatry · 2021Article
- Effects of centrifugation and whole-body vibrations on blood-brain barrier permeability in mice.NPJ microgravity · 2020Article
- Acclimation during space flight: effects on human emotion.Military Medical Research · 2016Review
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe weightlessness caused by prolonged bed rest results in changes in cerebral circulation and thus, brain functions, which is of interest.
methodsWe investigated the effects of 45-day, -6° head-down bed rest, which stimulated microgravity, on working memory in 16 healthy male participants. The 2-back task was used to test the working memory variations on the 2nd day before bed rest (R-2); on the 11th (R11), 20th (R20), 32nd (R32), and 40th (R40) days of bed rest; and on the eighth day after bed rest (R+8). The cognitive response and the physiological reactivity (such as galvanic skin response, heart rate, and heart rate variability) under the 2-back task were recorded simultaneously.
resultsThe results showed that compared with R-2, on the R+8, the participants' galvanic skin response increased significantly, and the high frequency of heart rate variability (HF), low frequency of heart rate variability (LF), and reaction time in the 2-back task decreased significantly. There were positive correlations between the participants' reaction time of working memory and the LF/HF under head-down bed rest (at R11, R20, and R32).
conclusionThe results suggested that the prolonged head-down bed rest may have a detrimental effect on individual physiology and working memory. Physiology indices, such as galvanic skin response and heart rate variability, were sensitive to the prolonged bed rest.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.