ArticleInternational journal of nanomedicine2015
Nanoscale TiO2 nanotubes govern the biological behavior of human glioma and osteosarcoma cells.
Article in International journal of nanomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Laminin Adsorption and Adhesion of Neurons and Glial Cells on Carbon Implanted Titania Nanotube Scaffolds for Neural Implant Applications.Nanomaterials (Basel, Switzerland) · 2022Article
- The Deposition of a Lectin fromBiomolecules · 2021Article
- Microbial Decontamination and Antibacterial Activity of Nanostructured Titanium Dental Implants: A Narrative Review.Nanomaterials (Basel, Switzerland) · 2021Review
- Surface engineering of titania nanotubes incorporated with double-layered extracellular vesicles to modulate inflammation and osteogenesis.Regenerative biomaterials · 2021Article
- Antibacterial activity of AgNPs-TiORSC advances · 2020Article
- Titanium dioxide nanoparticles induce endoplasmic reticulum stress-mediated apoptotic cell death in liver cancer cells.The Journal of international medical research · 2020Article
- Article
- Biocompatibility evaluation of antibacterial Ti-Ag alloys with nanotubular coatings.International journal of nanomedicine · 2019Article
- TiOFrontiers in chemistry · 2019Article
- Nanoscale TiOInternational journal of nanomedicine · 2017Article
- TiOInternational journal of nanomedicineReview
- Antibacterial abilities and biocompatibilities of Ti-Ag alloys with nanotubular coatings.International journal of nanomedicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells respond to their surroundings through an interactive adhesion process that has direct effects on cell proliferation and migration. This research was designed to investigate the effects of TiO2 nanotubes with different topographies and structures on the biological behavior of cultured cells. The results demonstrated that the nanotube diameter, rather than the crystalline structure of the coatings, was a major factor for the biological behavior of the cultured cells. The optimal diameter of the nanotubes was 20 nm for cell adhesion, migration, and proliferation in both glioma and osteosarcoma cells. The expression levels of vitronectin and phosphor-focal adhesion kinase were affected by the nanotube diameter; therefore, it is proposed that the responses of vitronectin and phosphor-focal adhesion kinase to the nanotube could modulate cell fate. In addition, the geometry and size of the nanotube coating could regulate the degree of expression of acetylated α-tubulin, thus indirectly modulating cell migration behavior. Moreover, the expression levels of apoptosis-associated proteins were influenced by the topography. In conclusion, a nanotube diameter of 20 nm was the critical threshold that upregulated the expression level of Bcl-2 and obviously decreased the expression levels of Bax and caspase-3. This information will be useful for future biomedical and clinical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.