Evidence map›Paper›PMID 25848253›Full record

ArticleInternational journal of nanomedicine2015

Water-soluble L-cysteine-coated FePt nanoparticles as dual MRI/CT imaging contrast agent for glioma.

Shuyan Liang, Qing Zhou, Min Wang, Yanhong Zhu, Qingzhi Wu, Xiangliang Yang

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Colloidally Stable P(DMA-AGME)-Ale-Coated Gd(Tb)FNanomaterials (Basel, Switzerland) · 2021
    Article
  9. Article
  10. Folic Acid-Conjugated CuFeSeInternational journal of nanomedicine · 2021
    Article
  11. Article
  12. Review
  13. Magnetic interactions andRSC advances · 2018
    Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuyan LiangCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Qing ZhouCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Min WangState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, People's Republic of China ; Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, People's Republic of China.
Yanhong ZhuCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Qingzhi WuState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, People's Republic of China ; Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, People's Republic of China.
Xiangliang YangCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanoparticles (NPs) are advantageous for the delivery of diagnosis agents to brain tumors. In this study, we attempted to develop an L-cysteine coated FePt (FePt-Cys) NP as MRI/CT imaging contrast agent for the diagnosis of malignant gliomas. FePt-Cys NPs were synthesized through a co-reduction route, which was characterized by transmission electron microscopy, high-resolution transmission electron microscopy, powder X-ray diffraction, Fourier transform infrared spectroscopy, and dynamic light scattering. The MRI and CT imaging ability of FePt-Cys NPs was evaluated using different gliomas cells (C6, SGH44, U251) as the model. Furthermore, the biocompatibility of the as-synthesized FePt-Cys NPs was evaluated using three different cell lines (ECV304, L929, and HEK293) as the model. The results showed that FePt-Cys NPs displayed excellent biocompatibility and good MRI/CT imaging ability, thereby indicating promising potential as a dual MRI/CT contrast agent for the diagnosis of brain malignant gliomas.

Indexed as

Contrast MediaCysteineGliomaHEK293 CellsHumansIronMagnetic Resonance ImagingMetal NanoparticlesPlatinumTomography, X-Ray ComputedContrast MediaCysteineIronPlatinumCTgliomaMRI

Identifiers

PMID25848253
PMCPMC4376264

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.