Evidence map›Paper›PMID 25848240›Full record

Observational studyClinical interventions in aging2015

Repeated vertebral augmentation for new vertebral compression fractures of postvertebral augmentation patients: a nationwide cohort study.

Cheng-Loong Liang, Hao-Kwan Wang, Fei-Kai Syu, Kuo-Wei Wang, Kang Lu, Po-Chou Liliang

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical interventions in aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Cheng-Loong LiangDepartment of Neurosurgery, E-Da Hospital, I-Shou University, Kaohsiung City, Taiwan.
Hao-Kwan WangDepartment of Neurosurgery, E-Da Hospital, I-Shou University, Kaohsiung City, Taiwan.
Fei-Kai SyuDepartment of Pharmacy, China Medical University Hospital, Taichung City, Taiwan.
Kuo-Wei WangDepartment of Neurosurgery, E-Da Hospital, I-Shou University, Kaohsiung City, Taiwan.
Kang LuDepartment of Neurosurgery, E-Da Hospital, I-Shou University, Kaohsiung City, Taiwan.
Po-Chou LiliangDepartment of Neurosurgery, E-Da Hospital, I-Shou University, Kaohsiung City, Taiwan.
I-Shou University · TWChina Medical University · TWE-Da Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePostvertebral augmentation vertebral compression fractures are common; repeated vertebral augmentation is usually performed for prompt pain relief. This study aimed to evaluate the incidence and risk factors of repeat vertebral augmentation.

methodsWe performed a retrospective, nationwide, population-based longitudinal observation study, using the National Health Insurance Research Database (NHIRD) of Taiwan. All patients who received vertebral augmentation for vertebral compression fractures were evaluated. The collected data included patient characteristics (demographics, comorbidities, and medication exposure) and repeat vertebral augmentation. Kaplan-Meier and stratified Cox proportional hazard regressions were performed for analyses.

resultsThe overall incidence of repeat vertebral augmentation was 11.3% during the follow-up until 2010. Patients with the following characteristics were at greater risk for repeat vertebral augmentation: female sex (AOR=1.24; 95% confidence interval [CI]: 1.10-2.36), advanced age (AOR=1.60; 95% CI: 1.32-2.08), diabetes mellitus (AOR=4.31; 95% CI: 4.05-5.88), cerebrovascular disease (AOR=4.09; 95% CI: 3.44-5.76), dementia (AOR=1.97; 95% CI: 1.69-2.33), blindness or low vision (AOR=3.72; 95% CI: 2.32-3.95), hypertension (AOR=2.58; 95% CI: 2.35-3.47), and hyperlipidemia (AOR=2.09; 95% CI: 1.67-2.22). Patients taking calcium/vitamin D (AOR=2.98; 95% CI: 1.83-3.93), bisphosphonates (AOR=2.11; 95% CI: 1.26-2.61), or calcitonin (AOR=4.59; 95% CI: 3.40-5.77) were less likely to undergo repeat vertebral augmentation; however, those taking steroids (AOR=7.28; 95% CI: 6.32-8.08), acetaminophen (AOR=3.54; 95% CI: 2.75-4.83), or nonsteroidal anti-inflammatory drugs (NSAIDs) (AOR=6.14; 95% CI: 5.08-7.41) were more likely to undergo repeat vertebral augmentation.

conclusionWe conclude that the incidence of repeat vertebral augmentation is rather high. An understanding of risk factors predicting repeat vertebral augmentation provides valuable basis to improve health care for geriatric populations.

Indexed as

AgedAged, 80 and overAge FactorsComorbidityFemaleFractures, CompressionHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedProportional Hazards ModelsReoperationRisk FactorsSex FactorsSpinal Fracturesbisphosphonatecomorbiditykyphoplastyold agevertebroplasty

Identifiers

PMID25848240
PMCPMC4381902
OpenAlexW2112511375

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.