ArticleCarbon2016
Wrinkled, wavelength-tunable graphene-based surface topographies for directing cell alignment and morphology.
Article in Carbon, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- The Application of Flexible Graphene Field-Effect Transistor Sensors in Multidimensional Biosensing and Precision Medicine.Materials (Basel, Switzerland) · 2026Review
- Harnessing Surface Instabilities for Functional Materials: Mechanics, Morphology, and Emerging Applications.Nano-micro letters · 2026Review
- Non-enzymatic electrochemical glucose sensing using flexible rGO/AgNW@PANI composite films on nylon substrates.RSC advances · 2026Article
- Thermally Driven Wrinkle Realignment for Morphology-Controlled Enhancement of Dry Adhesion Performance.ACS applied materials & interfaces · 2025Article
- Regulation of nanomaterials in peripheral nerve regeneration from a microenvironmental perspective: biological effects and mechanisms.Materials today. Bio · 2025Review
- Development of Soft Wrinkled Micropatterns on the Surface of 3D-Printed Hydrogel-Based Scaffolds via High-Resolution Digital Light Processing.Gels (Basel, Switzerland) · 2024Article
- Dynamic regulation of stem cell adhesion and differentiation on degradable piezoelectric poly (L-lactic acid) (PLLA) nanofibers.Biomedical engineering letters · 2024Article
- Article
- Tuning the Topography of Dynamic 3D Scaffolds through Functional Protein Wrinkled Coatings.Polymers · 2024Article
- Skeletal muscle cells opto-stimulation by intramembrane molecular transducers.Communications biology · 2023Article
- Surface Functionalization of 4D Printed Substrates Using Polymeric and Metallic Wrinkles.Polymers · 2023Article
- Wrinkled Interfaces: Taking Advantage of Anisotropic Wrinkling to Periodically Pattern Polymer Surfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Phenotypic change of mesenchymal stem cells into smooth muscle cells regulated by dynamic cell-surface interactions on patterned arrays of ultrathin graphene oxide substrates.Journal of nanobiotechnology · 2022Article
- The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems.Cell communication and signaling : CCS · 2021Review
- Controlling nanochannel orientation and dimensions in graphene-based nanofluidic membranes.Nature communications · 2021Article
- Bioinspired Multiscale Wrinkling Patterns on Curved Substrates: An Overview.Nano-micro letters · 2020Review
- Mechanochemical engineering of 2D materials for multiscale biointerfaces.Journal of materials chemistry. B · 2019Review
- Mosaic pattern formation in exfoliated graphene by mechanical deformation.Nature communications · 2019Article
- Uniaxially crumpled graphene as a platform for guided myotube formation.Microsystems & nanoengineering · 2019Article
- Multifaceted Biomedical Applications of Functional Graphene Nanomaterials to Coated Substrates, Patterned Arrays and Hybrid Scaffolds.Nanomaterials (Basel, Switzerland) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Textured surfaces with periodic topographical features and long-range order are highly attractive for directing cell-material interactions. They mimic physiological environments more accurately than planar surfaces and can fundamentally alter cell alignment, shape, gene expression, and cellular assembly into superstructures or microtissues. Here we demonstrate for the first time that wrinkled graphene-based surfaces are suitable as textured cell attachment substrates, and that engineered wrinkling can dramatically alter cell alignment and morphology. The wrinkled surfaces are fabricated by graphene oxide wet deposition onto pre-stretched elastomers followed by relaxation and mild thermal treatment to stabilize the films in cell culture medium. Multilayer graphene oxide films form periodic, delaminated buckle textures whose wavelengths and amplitudes can be systematically tuned by variation in the wet deposition process. Human and murine fibroblasts attach to these textured films and remain viable, while developing pronounced alignment and elongation relative to those on planar graphene controls. Compared to lithographic patterning of nanogratings, this method has advantages in the simplicity and scalability of fabrication, as well as the opportunity to couple the use of topographic cues with the unique conductive, adsorptive, or barrier properties of graphene materials for functional biomedical devices.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.