ArticleProceedings of the National Academy of Sciences of the United States of America2015
Ovary ecdysteroidogenic hormone requires a receptor tyrosine kinase to activate egg formation in the mosquito Aedes aegypti.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57 citing papers in PubMed, 116 citations in OpenAlex.
- The Neuropeptide Neuroparsin-A Regulates the Establishment of Dominance Hierarchy in Bumblebees.International journal of molecular sciences · 2025Article
- Temporal changes in amino acid profiles coordinate mosquito physiology and egg maturation in Aedes aegypti.BMC biology · 2025Article
- Insulin-like peptides activate egg formation in the Asian malaria mosquito Anopheles stephensi.Parasites & vectors · 2025Article
- Neuropeptides specify and reprogram division of labor in the leafcutter ant Atta cephalotes.Cell · 2025Article
- Influence of blood feeding and infection on arthropod hemocytes.Current opinion in insect science · 2025Review
- Multi-omics profiling reveals associations between gut microbiota and olfactory gene expression in mosquitoes.Frontiers in cellular and infection microbiology · 2025Article
- Neuropeptides specify and reprogram division of labor in the leafcutter antbioRxiv : the preprint server for biology · 2024Article
- Cephalic ganglia transcriptomics of the American cockroach Periplaneta americana (Blattodea: Blattidae).Journal of insect science (Online) · 2024Article
- An evolutionarily conserved pathway mediated by neuroparsin-A regulates reproductive plasticity in ants.PLoS biology · 2024Article
- Insulin-like peptides and ovary ecdysteroidogenic hormone differentially stimulate physiological processes regulating egg formation in the mosquito Aedes aegypti.Insect biochemistry and molecular biology · 2023Article
- Amino acid-dependent regulation of insulin-like peptide signaling is mediated by TOR and GATA factors in the disease vector mosquitoProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Fertility decline in female mosquitoes is regulated by theiScience · 2023Article
- RNAi-mediated knockdown of two orphan G protein-coupled receptors reduces fecundity in the yellow fever mosquitoFrontiers in insect science · 2023Article
- Article
- Insulin-like peptide 3 stimulates hemocytes to proliferate in anautogenous and facultatively autogenous mosquitoes.The Journal of experimental biology · 2022Article
- Article
- Genome-Wide Identification of Neuropeptides and Their Receptors in an Aphid Endoparasitoid Wasp,Insects · 2021Article
- Review
- Anopheles coluzzii stearoyl-CoA desaturase is essential for adult female survival and reproduction upon blood feeding.PLoS pathogens · 2021Article
- Whole blood and blood components from vertebrates differentially affect egg formation in three species of anautogenous mosquitoes.Parasites & vectors · 2021Article
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3 authors at 1 institution in 1 country.
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Abstract
Mosquitoes are major disease vectors because most species must feed on blood from a vertebrate host to produce eggs. Blood feeding by the vector mosquito Aedes aegypti triggers the release of two neurohormones, ovary ecdysteroidogenic hormone (OEH) and insulin-like peptides (ILPs), which activate multiple processes required for egg formation. ILPs function by binding to the insulin receptor, which activates downstream components in the canonical insulin signaling pathway. OEH in contrast belongs to a neuropeptide family called neuroparsins, whose receptor is unknown. Here we demonstrate that a previously orphanized receptor tyrosine kinase (RTK) from A. aegypti encoded by the gene AAEL001915 is an OEH receptor. Phylogenetic studies indicated that the protein encoded by this gene, designated AAEL001915, belongs to a clade of RTKs related to the insulin receptor, which are distinguished by an extracellular Venus flytrap module. Knockdown of AAEL001915 by RNAi disabled OEH-mediated egg formation in A. aegypti. AAEL001915 was primarily detected in the mosquito ovary in association with follicular epithelial cells. Both monomeric and dimeric AAEL001915 were detected in mosquito ovaries and transfected Drosophila S2 cells. Functional assays further indicated that OEH bound to dimeric AAEL001915, which resulted in downstream phosphorylation of Ak strain transforming factor (Akt). We hypothesize that orthologs of AAEL001915 in other insects are neuroparsin receptors.
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