ArticleProceedings of the National Academy of Sciences of the United States of America2015
fMRI of the rod scotoma elucidates cortical rod pathways and implications for lesion measurements.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
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- Achromatopsia-Visual Cortex Stability and Plasticity in the Absence of Functional Cones.Investigative ophthalmology & visual science · 2023Article
- Cortical field maps across human sensory cortex.Frontiers in computational neuroscience · 2023Review
- Highly accurate retinotopic maps of the physiological blind spot in human visual cortex.Human brain mapping · 2022Article
- A demonstration of cone function plasticity after gene therapy in achromatopsia.Brain : a journal of neurology · 2022Article
- Pitfalls in post hoc analyses of population receptive field data.NeuroImage · 2022Article
- Implications of Neural Plasticity in Retinal Prosthesis.Investigative ophthalmology & visual science · 2022Article
- Macaque Area V2/V3 Reorganization Following Homonymous Retinal Lesions.Frontiers in neuroscience · 2022Article
- Mapping Visual Field Defects With fMRI - Impact of Approach and Experimental Conditions.Frontiers in neuroscience · 2021Article
- Functional Dynamics of Deafferented Early Visual Cortex in Glaucoma.Frontiers in neuroscience · 2021Article
- Rapid topographic reorganization in adult human primary visual cortex (V1) during noninvasive and reversible deprivation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Cerebral Modifications and Visual Pathway Reorganization in Maculopathy: A Systematic Review.Frontiers in neuroscience · 2020Review
- Humans Trust Central Vision More Than Peripheral Vision Even in the Dark.Current biology : CB · 2019Article
- Studying Cortical Plasticity in Ophthalmic and Neurological Disorders: From Stimulus-Driven to Cortical Circuitry Modeling Approaches.Neural plasticity · 2019Review
- Establishing Wiring Specificity in Visual System Circuits: From the Retina to the Brain.Annual review of neuroscience · 2017Review
- Visual Field Map Clusters in High-Order Visual Processing: Organization of V3A/V3B and a New Cloverleaf Cluster in the Posterior Superior Temporal Sulcus.Frontiers in integrative neuroscience · 2017Article
- Primary visual cortical remapping in patients with inherited peripheral retinal degeneration.NeuroImage. Clinical · 2017Article
- Visual Cortex Plasticity Following Peripheral Damage To The Visual System: fMRI Evidence.Current neurology and neuroscience reports · 2016Review
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2 authors at 1 institution in 1 country.
Funding
Abstract
Are silencing, ectopic shifts, and receptive field (RF) scaling in cortical scotoma projection zones (SPZs) the result of long-term reorganization (plasticity) or short-term adaptation? Electrophysiological studies of SPZs after retinal lesions in animal models remain controversial, because they are unable to conclusively answer this question because of limitations of the methodology. Here, we used functional MRI (fMRI) visual field mapping through population RF (pRF) modeling with moving bar stimuli under photopic and scotopic conditions to measure the effects of the rod scotoma in human early visual cortex. As a naturally occurring central scotoma, it has a large cortical representation, is free of traumatic lesion complications, is completely reversible, and has not reorganized under normal conditions (but can as seen in rod monochromats). We found that the pRFs overlapping the SPZ in V1, V2, V3, hV4, and VO-1 generally (i) reduced their blood oxygen level-dependent signal coherence and (ii) shifted their pRFs more eccentric but (iii) scaled their pRF sizes in variable ways. Thus, silencing, ectopic shifts, and pRF scaling in SPZs are not unique identifiers of cortical reorganization; rather, they can be the expected result of short-term adaptation. However, are there differences between rod and cone signals in V1, V2, V3, hV4, and VO-1? We did not find differences for all five maps in more peripheral eccentricities outside of rod scotoma influence in coherence, eccentricity representation, or pRF size. Thus, rod and cone signals seem to be processed similarly in cortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.