ArticleProceedings of the National Academy of Sciences of the United States of America2015
Mosaic nature of the mitochondrial proteome: Implications for the origin and evolution of mitochondria.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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Who cites it
88 citing papers in PubMed, 169 citations in OpenAlex.
- Mitochondrial OXPHOS restricts SARS-CoV-2 replication.Science advances · 2026Article
- Sensitivity of genome-wide tests for mitonuclear genetic incompatibilities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
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- Mitonuclear Discordance of Beetles Shaped by Incomplete Lineage Sorting and Introgression Under Loose Interaction Mechanism.Molecular biology and evolution · 2025Article
- Tracing the evolutionary pathway: on the origin of mitochondria and eukaryogenesis.The FEBS journal · 2025Article
- Mitochondria - the CEO of the cell.Journal of cell science · 2025Review
- Origin and evolution of mitochondrial inner membrane composition.Journal of cell science · 2025Review
- Chloroplasts with clefts and holes: a reassessment of the chloroplast shape using 3D FE-SEM cellular reconstruction of two species of Chlamydomonas.Protoplasma · 2025Article
- Reconstructing the last common ancestor of all eukaryotes.PLoS biology · 2024Review
- Horizontal gene transfer in eukaryotes: aligning theory with data.Nature reviews. Genetics · 2024Review
- Polyploid plants take cytonuclear perturbations in stride.The Plant cell · 2024Article
- Comparative analysis of chloroplast and mitochondrial genomes of sweet potato provides evidence of gene transfer.Scientific reports · 2024Article
- Mitochondrial microproteins: critical regulators of protein import, energy production, stress response pathways, and programmed cell death.American journal of physiology. Cell physiology · 2023Review
- Miniature RNAs are embedded in an exceptionally protein-rich mitoribosome via an elaborate assembly pathway.Nucleic acids research · 2023Article
- An excavate root for the eukaryote tree of life.Science advances · 2023Article
- Metabolic compatibility and the rarity of prokaryote endosymbioses.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes.Antioxidants (Basel, Switzerland) · 2023Review
- MRPS36 provides a structural link in the eukaryotic 2-oxoglutarate dehydrogenase complex.Open biology · 2023Article
- Mitochondrial dynamics in macrophages: divide to conquer or unite to survive?Biochemical Society transactions · 2023Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Comparative studies of the mitochondrial proteome have identified a conserved core of proteins descended from the α-proteobacterial endosymbiont that gave rise to the mitochondrion and was the source of the mitochondrial genome in contemporary eukaryotes. A surprising result of phylogenetic analyses is the relatively small proportion (10-20%) of the mitochondrial proteome displaying a clear α-proteobacterial ancestry. A large fraction of mitochondrial proteins typically has detectable homologs only in other eukaryotes and is presumed to represent proteins that emerged specifically within eukaryotes. A further significant fraction of the mitochondrial proteome consists of proteins with homologs in prokaryotes, but without a robust phylogenetic signal affiliating them with specific prokaryotic lineages. The presumptive evolutionary source of these proteins is quite different in contending models of mitochondrial origin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.