ArticleProceedings of the National Academy of Sciences of the United States of America2015
Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 65 citations in OpenAlex.
- Diversity and Novelty of Venom Peptides in Vermivorous Cone Snails, SubgenusMarine drugs · 2025Article
- Macrocycles of Saxitoxin: Insights into the Structure of Zetekitoxin AB.Chembiochem : a European journal of chemical biology · 2025Article
- Article
- Prey Shifts Drive Venom Evolution in Cone Snails.Molecular biology and evolution · 2024Article
- Using Constellation Pharmacology to Characterize a Novel α-Conotoxin fromMarine drugs · 2024Article
- Review
- Comparative Analysis of Alpha-1 Orthosteric-Site Binding by a Clade of Central American Pit Vipers (GeneraToxins · 2023Article
- Coordinated adaptations define the ontogenetic shift from worm- to fish-hunting in a venomous cone snail.Nature communications · 2023Article
- Historical Perspective of the Characterization of Conotoxins Targeting Voltage-Gated Sodium Channels.Marine drugs · 2023Review
- Principal Component and Structural Element Analysis Provide Insights into the Evolutionary Divergence of Conotoxins.Biology · 2022Article
- Unconventional insulins from predators and pathogens.Nature chemical biology · 2022Review
- Reconstructing the Origins of the Somatostatin and Allatostatin-C Signaling Systems Using the Accelerated Evolution of Biodiverse Cone Snail Toxins.Molecular biology and evolution · 2022Article
- Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads.Science advances · 2022Article
- Venom duct origins of prey capture and defensive conotoxins in piscivorous Conus striatus.Scientific reports · 2021Article
- The complete mitochondrial DNA genome of a cone snail,Mitochondrial DNA. Part B, Resources · 2021Article
- Small-molecule mimicry hunting strategy in the imperial cone snail,Science advances · 2021Article
- Non-Peptidic Small Molecule Components from Cone Snail Venoms.Frontiers in pharmacology · 2021Review
- Hormone-like conopeptides - new tools for pharmaceutical design.RSC medicinal chemistry · 2020Review
- Identification of Conomarphin Variants in theMarine drugs · 2020Article
- Molecular game theory for a toxin-dominant food chain model.National science review · 2019Article
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Authors and funding
13 authors at 5 institutions in 5 countries.
Funding
Abstract
Prey shifts in carnivorous predators are events that can initiate the accelerated generation of new biodiversity. However, it is seldom possible to reconstruct how the change in prey preference occurred. Here we describe an evolutionary "smoking gun" that illuminates the transition from worm hunting to fish hunting among marine cone snails, resulting in the adaptive radiation of fish-hunting lineages comprising ∼100 piscivorous Conus species. This smoking gun is δ-conotoxin TsVIA, a peptide from the venom of Conus tessulatus that delays inactivation of vertebrate voltage-gated sodium channels. C. tessulatus is a species in a worm-hunting clade, which is phylogenetically closely related to the fish-hunting cone snail specialists. The discovery of a δ-conotoxin that potently acts on vertebrate sodium channels in the venom of a worm-hunting cone snail suggests that a closely related ancestral toxin enabled the transition from worm hunting to fish hunting, as δ-conotoxins are highly conserved among fish hunters and critical to their mechanism of prey capture; this peptide, δ-conotoxin TsVIA, has striking sequence similarity to these δ-conotoxins from piscivorous cone snail venoms. Calcium-imaging studies on dissociated dorsal root ganglion (DRG) neurons revealed the peptide's putative molecular target (voltage-gated sodium channels) and mechanism of action (inhibition of channel inactivation). The results were confirmed by electrophysiology. This work demonstrates how elucidating the specific interactions between toxins and receptors from phylogenetically well-defined lineages can uncover molecular mechanisms that underlie significant evolutionary transitions.
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