ArticleProceedings of the National Academy of Sciences of the United States of America2015
Time-dependent sequestration of RVE8 by LNK proteins shapes the diurnal oscillation of anthocyanin biosynthesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 92 citations in OpenAlex.
- XAP5 CIRCADIAN TIMEKEEPER coordinates circadian rhythms and anthocyanin biosynthesis independently of splicing.Plant physiology · 2026Article
- Genome-wide analysis of Zoysia japonica REVEILLE family identifies ZjRVE8-1 as a positive cold-tolerance regulator.Plant cell reports · 2025Article
- Aquilaria sinensis MYB-Like Transcription Factor AsMYB1 Promotes 2-(2-Phenylethyl)Chromone Biosynthesis Through Interacting With 14-3-3 Family Protein AsGRF1.Plant biotechnology journal · 2025Article
- Transcriptional activation and repression in the plant circadian clock: Revisiting core oscillator feedback loops and output pathways.Plant communications · 2025Review
- Integrative metabolome and genome-wide transcriptome analyses reveal the regulatory network for bioactive compound biosynthesis in lettuce upon UV-A radiation.Molecular horticulture · 2025Article
- Abundant clock proteins point to missing molecular regulation in the plant circadian clock.Molecular systems biology · 2025Article
- Light regulates the synthesis and accumulation of plant secondary metabolites.Frontiers in plant science · 2025Review
- Article
- Effects of light regimes on circadian gene co-expression networks inPlant direct · 2024Article
- Unlocking Nature's Rhythms: Insights into Secondary Metabolite Modulation by the Circadian Clock.International journal of molecular sciences · 2024Review
- Integrated transcriptome and metabolome analysis reveals anthocyanin biosynthesis mechanisms in pepper (Capsicum annuum L.) leaves under continuous blue light irradiation.BMC plant biology · 2024Article
- Differential Response of MYB Transcription Factor Gene Transcripts to Circadian Rhythm in Tea Plants (International journal of molecular sciences · 2024Article
- CstMYB1R1, a REVEILLE-8-like transcription factor, regulates diurnal clock-specific anthocyanin biosynthesis and response to abiotic stress in Crocus sativus L.Plant cell reports · 2023Article
- RVE2, a new regulatory factor in jasmonic acid pathway, orchestrates resistance to Verticillium wilt.Plant biotechnology journal · 2023Article
- Characteristics and Functions of MYB (v-Myb avivan myoblastsis virus oncogene homolog)-Related Genes inGenes · 2023Review
- COLD REGULATED GENE 27 and 28 antagonize the transcriptional activity of the RVE8/LNK1/LNK2 circadian complex.Plant physiology · 2023Article
- New insights into the regulation of plant metabolism by O-acetylserine: sulfate and beyond.Journal of experimental botany · 2023Article
- Clock-regulated coactivators selectively control gene expression in response to different temperature stress conditions inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Characterization of the REVEILLE family in Rosaceae and role of PbLHY in flowering time regulation.BMC genomics · 2023Article
- Potential regulatory genes of light induced anthocyanin accumulation in sweet cherry identified by combining transcriptome and metabolome analysis.Frontiers in plant science · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circadian clocks sustain 24-h rhythms in physiology and metabolism that are synchronized with the day/night cycle. In plants, the regulatory network responsible for the generation of rhythms has been broadly investigated over the past years. However, little is known about the intersecting pathways that link the environmental signals with rhythms in cellular metabolism. Here, we examine the role of the circadian components REVEILLE8/LHY-CCA1-LIKE5 (RVE8/LCL5) and NIGHT LIGHT-INDUCIBLE AND CLOCK-REGULATED genes (LNK) shaping the diurnal oscillation of the anthocyanin metabolic pathway. Around dawn, RVE8 up-regulates anthocyanin gene expression by directly associating to the promoters of a subset of anthocyanin biosynthetic genes. The up-regulation is overcome at midday by the repressing activity of LNK proteins, as inferred by the increased anthocyanin gene expression in lnk1/lnk2 double mutant plants. Chromatin immunoprecipitation assays using LNK and RVE8 misexpressing plants show that RVE8 binding to target promoters is precluded in LNK overexpressing plants and conversely, binding is enhanced in the absence of functional LNKs, which provides a mechanism by which LNKs antagonize RVE8 function in the regulation of anthocyanin accumulation. Based on their previously described transcriptional coactivating function, our study defines a switch in the regulatory activity of RVE8-LNK interaction, from a synergic coactivating role of evening-expressed clock genes to a repressive antagonistic function modulating anthocyanin biosynthesis around midday.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.