Evidence map›Paper›PMID 25847290›Full record

ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2016

Smoking Status Confirmation by Proxy: Validation in a Smoking Cessation Trial.

Susan Regan, Zachary Z Reid, Jennifer H K Kelley, Michele Reyen, Molly Korotkin, Sandra J Japuntich, Joseph C Viana, Douglas E Levy, Nancy A Rigotti

Open access · bronzeAbstract read
In one paragraph

Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. A Scoping Review and Meta-analysis of the Use of Remote Biochemical Verification Methods of Smoking Status in Tobacco Research.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023
    Pooled it
  2. Telephone counselling for smoking cessation.The Cochrane database of systematic reviews · 2019
    Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Biochemical verification of tobacco use in ICU patients using point-of-care urinary cotinine.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026
    Article
  7. Article
  8. Accuracy of Smoking Status Reporting: Proxy Information in a Rapidly Fatal Cancer Setting.Mayo Clinic proceedings. Innovations, quality & outcomes · 2020
    Article
  9. Tobacco Use and Subsequent Cessation Among Hospitalized Patients in Mumbai, India: A Longitudinal Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020
    Observational
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Susan ReganTobacco Research and Treatment Center, Massachusetts General Hospital, Boston, MA; Department of Medicine, Harvard Medical School, Boston, MA; sregan@partners.org.
Zachary Z ReidTobacco Research and Treatment Center, Massachusetts General Hospital, Boston, MA;
Jennifer H K KelleyTobacco Research and Treatment Center, Massachusetts General Hospital, Boston, MA; Mongan Institute for Health Policy, Massachusetts General Hospital, Boston, MA;
Michele ReyenTobacco Research and Treatment Center, Massachusetts General Hospital, Boston, MA;
Molly KorotkinTobacco Research and Treatment Center, Massachusetts General Hospital, Boston, MA; Mongan Institute for Health Policy, Massachusetts General Hospital, Boston, MA;
Sandra J JapuntichTobacco Research and Treatment Center, Massachusetts General Hospital, Boston, MA; National Center for PTSD, VA Boston Healthcare System, Boston, MA;
Joseph C VianaTobacco Research and Treatment Center, Massachusetts General Hospital, Boston, MA; Department of Health Policy and Management, University of California, Los Angeles, CA.
Douglas E LevyTobacco Research and Treatment Center, Massachusetts General Hospital, Boston, MA; Department of Medicine, Harvard Medical School, Boston, MA; Mongan Institute for Health Policy, Massachusetts General Hospital, Boston, MA;
Nancy A RigottiTobacco Research and Treatment Center, Massachusetts General Hospital, Boston, MA; Department of Medicine, Harvard Medical School, Boston, MA; Mongan Institute for Health Policy, Massachusetts General Hospital, Boston, MA;
Massachusetts General Hospital · USHarvard University · USMGH Institute of Health Professions · US

Funding

Smoking Cessation Interventions for Health Care SettingsK24HL004440 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI RIGOTTI, NANCY A · 2000 to 2009
$1.5M
Smoking Interventions for Hospital Patients:A Comparative Effectiveness TrialRC1HL099668 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI RIGOTTI, NANCY A · 2009 to 2010
$996k
NHLBI NIH HHS K24 HL004440NHLBI NIH HHS RC1 HL099668
6 · The paper itself

Abstract

introductionBiochemical confirmation (BC) of self-report is the gold standard of evidence for abstinence in smoking cessation research, but difficulty in obtaining samples may bias estimates of quit rates. Proxy confirmation (PC) has not been validated in cessation trials. We assessed the feasibility and validity of PC in a cessation trial for hospitalized smokers.

methodsWe enrolled 402 daily cigarette smokers during a hospital admission. At enrollment, participants provided demographics, smoking history, and named proxies to confirm their smoking status at follow-up. Participants provided self-reported (SR) 7-day tobacco abstinence by telephone at 6 months post-discharge. SR quitters were asked to mail a saliva sample for BC. Incentives were offered for survey completion ($20) and returned samples ($50). We called proxies for all those with SR to obtain PC. Quit rates were calculated with missing data indicating smoking. We assessed associations of nonresponse with baseline characteristics using chi-squared tests and logistic regression. We calculated the sensitivity and specificity of PC in detecting smokers as determined by BC.

resultsAll patients named at least one proxy. Response rates were 82% for SR, 84% for PC, and 69% for BC. Observed participant characteristics were unrelated to provision of sample for BC. Estimated quit rates were 35% for SR, 27% for SR + PC, 21% for SR + BC and 27% for SR + BC or PC. Sensitivity of PC was not higher than SR (73% vs. 77%); specificity was lower (84% vs. 100%).

conclusionPC was feasible but not superior to self-report in a cessation trial.

Indexed as

MotivationSmoking PreventionCotinineFemaleHospitalizationHumansLogistic ModelsMaleMiddle AgedPatient DischargeReproducibility of ResultsSalviaSelf ReportSmoking CessationTelephoneTobacco Use DisorderCotinine

Identifiers

PMID25847290
PMCPMC4707186
OpenAlexW2320164660

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.