ArticleMuscle & nerve2016
Age-related T2 changes in hindlimb muscles of mdx mice.
Article in Muscle & nerve, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Using MRI to quantify skeletal muscle pathology in Duchenne muscular dystrophy: A systematic mapping review.Muscle & nerve · 2021Pooled it
- Quantitative MRI Assessment of Myotoxin-Induced Skeletal Muscle Damage of mdx Mice.Muscle & nerve · 2026Article
- Electrical impedance myography detects dystrophin-related muscle changes in mdx mice.Skeletal muscle · 2023Article
- Magnetic resonance quantification of skeletal muscle lipid infiltration in a humanized mouse model of Duchenne muscular dystrophy.NMR in biomedicine · 2023Article
- Effects of muscle damage onNMR in biomedicine · 2022Article
- Effects of PDE5 inhibition on dystrophic muscle following an acute bout of downhill running and endurance training.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Age-dependent changes in metabolite profile and lipid saturation in dystrophic mice.NMR in biomedicine · 2019Article
- Non-invasive tracking of disease progression in young dystrophic muscles using multi-parametric MRI at 14T.PloS one · 2018Article
- Validation of ultrasonography for non-invasive assessment of diaphragm function in muscular dystrophy.The Journal of physiology · 2016Article
- Eliminating Nox2 reactive oxygen species production protects dystrophic skeletal muscle from pathological calcium influx assessed in vivo by manganese-enhanced magnetic resonance imaging.The Journal of physiology · 2016Article
- Near-Infrared Optical Imaging Noninvasively Detects Acutely Damaged Muscle.The American journal of pathology · 2016Article
- Skeletal Muscle Quantitative Nuclear Magnetic Resonance Imaging and Spectroscopy as an Outcome Measure for Clinical Trials.Journal of neuromuscular diseases · 2016Review
- Article
- Contrast-Enhanced Near-Infrared Optical Imaging Detects Exacerbation and Amelioration of Murine Muscular Dystrophy.Molecular imagingArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionMagnetic resonance imaging (MRI) was used to monitor changes in the transverse relaxation time constant (T2) in lower hindlimb muscles of mdx mice at different ages.
methodsYoung (5 weeks), adult (44 weeks), and old mdx (96 weeks), and age-matched control mice were studied. Young mdx mice were imaged longitudinally, whereas adult and old mdx mice were imaged at a single time-point.
resultsMean muscle T2 and percent of pixels with elevated T2 were significantly different between mdx and control mice at all ages. In young mdx mice, mean muscle T2 peaked at 7-8 weeks and declined at 9-11 weeks. In old mdx mice, mean muscle T2 was decreased compared with young and adult mice, which could be attributed to fibrosis.
conclusionsMRI captured longitudinal changes in skeletal muscle integrity of mdx mice. This information will be valuable for pre-clinical testing of potential therapeutic interventions for muscular dystrophy.
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