Trial reportWorld journal of pediatrics : WJP2016
Effects of Bifidobacterium supplementation on intestinal microbiota composition and the immune response in healthy infants.
Trial report in World journal of pediatrics : WJP, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 5 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Probiotics in infants for prevention of allergic disease.The Cochrane database of systematic reviews · 2025Pooled it
- Effectiveness and safety study of formula containing probiotics, prebiotics, synbiotics on fullterm infants' growth - a systematic review and meta-analysis of randomized controlled study.European journal of clinical nutrition · 2025Pooled it
- Probiotics and the Potential of Genetic Modification as a Possible Treatment for Food Allergy.Nutrients · 2023Pooled it
- Effects of prebiotics, probiotics, and synbiotics on the infant gut microbiota and other health outcomes: A systematic review.Critical reviews in food science and nutrition · 2023Pooled it
- Pooled it
- Assessment trial of the effect of enteral insulin on the preterm infant intestinal microbiota.Pediatric research · 2024Trial
- Trial
- Probiotic supplementation promotes bone development, immune maturation, and cognitive function in growing mice.Journal of the science of food and agriculture · 2026Article
- Isolation and Characterization of Bifidobacterium longum A1, an Isolate from Faeces of an Exclusively Breast-fed Infant with Probiotic Potential.Probiotics and antimicrobial proteins · 2026Article
- Current Understanding of Probiotic Strains and Immune Function: From Gut Microbiota to Systemic Immunity.International journal of molecular sciences · 2026Review
- Insights into the mechanism of intestinal flora imbalance and immune disorder in co-morbidity of pneumonia and diarrhea in children.Frontiers in pediatrics · 2026Review
- The AhR-TLR4 axis in non-IgE-mediated Cow's milk allergy: a systematic review with integrated multi-omics corroboration.Frontiers in allergy · 2026Review
- The Microecological-Immune Axis in Pediatric Allergic Diseases: Imbalance Mechanisms and Regulatory Interventions.Nutrients · 2025Review
- Functional Significance of Probiotic Bacterial Interactions with Milk Fat Globules in a Human Host.Microorganisms · 2025Review
- Pediatric kidney transplant recipients are at an increased risk for dysbiosis.Frontiers in microbiology · 2025Article
- Potential of Synbiotics and Probiotics as Chemopreventive Agent.Probiotics and antimicrobial proteins · 2024Review
- Sequential early-life viral infections modulate the microbiota and adaptive immune responses to systemic and mucosal vaccination.PLoS pathogens · 2024Article
- Understanding the influence of the microbiome on childhood infections.Expert review of anti-infective therapy · 2024Review
- Deciphering the Potential of Probiotics in Vaccines.Vaccines · 2024Review
- Studies of the Impact of the Bifidobacterium Species on Inducible Nitric Oxide Synthase Expression and Nitric Oxide Production in Murine Macrophages of the BMDM Cell Line.Probiotics and antimicrobial proteins · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntestinal microbiotas are thought to be the most important source of maturational stimuli to the development of the immune system. However, few studies have focused on the development of T helper (Th) 1 immune response and antibody response to vaccinations in healthy infants, especially in a large cohort. Through this randomized, double-blind control trial, we investigated the effects of Bifidobacterium longum BB536 (BB536) supplementation on intestinal microbiota composition and the immune response in term infants.
methodsIn total, 300 healthy newborns were recruited, randomized and fed formula either supplemented with BB536 or with no supplementation. Stool samples were analyzed at months 2, 4 and 11. The representative cytokine for Th1 [interferon-γ (IFN-γ)] and Th2 [interleukin-4 (IL-4)] secretion cells were measured using enzyme-linked immunospot assay at 4 and 7 months of age. The antibody response to vaccines was measured at months 7 and 11.
resultsA total of 264 infants completed the study. The amount of bifidobacteria and the bifidobacteria/ Enterobacteriaceae ratio (B/E) were significantly higher in the BB536 supplementation group at months 2 and 4. The number of IFN-γ secretion cells and the ratio of IFN-γ/IL-4 secretion cells were increased in the BB536 supplementation group at 7 months. Moreover, the higher value of B/E in the early stages seems to be related to the increased Th1 response. No difference was observed between groups in the antibody response after vaccination.
conclusionBB536 has positive effects on establishing a healthy intestinal microbiota early in life, and it also plays an important role in improving the Th1 immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.