Evidence map›Paper›PMID 25845980›Full record

ArticleExperimental gerontology2015

Association of telomere length and mitochondrial DNA copy number in a community sample of healthy adults.

Audrey R Tyrka, Linda L Carpenter, Hung-Teh Kao, Barbara Porton, Noah S Philip, Samuel J Ridout, Kathryn K Ridout, Lawrence H Price

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental gerontology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 3 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 3 syntheses or guidelines pooled it, 120 citations in OpenAlex.

  1. Pooled it
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  4. Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Audrey R TyrkaMood Disorders Research Program and Laboratory for Clinical and Translational Neuroscience, Butler Hospital, Providence, RI, USA; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, USA. Electronic address: Audrey_Tyrka@Brown.edu.
Linda L CarpenterMood Disorders Research Program and Laboratory for Clinical and Translational Neuroscience, Butler Hospital, Providence, RI, USA; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, USA.
Hung-Teh KaoDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown University, USA; Laboratory of Molecular Psychiatry, Butler Hospital, Providence, RI, USA.
Barbara PortonDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown University, USA; Laboratory of Molecular Psychiatry, Butler Hospital, Providence, RI, USA.
Noah S PhilipMood Disorders Research Program and Laboratory for Clinical and Translational Neuroscience, Butler Hospital, Providence, RI, USA; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, USA.
Samuel J RidoutMood Disorders Research Program and Laboratory for Clinical and Translational Neuroscience, Butler Hospital, Providence, RI, USA; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, USA.
Kathryn K RidoutMood Disorders Research Program and Laboratory for Clinical and Translational Neuroscience, Butler Hospital, Providence, RI, USA; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, USA.
Lawrence H PriceMood Disorders Research Program and Laboratory for Clinical and Translational Neuroscience, Butler Hospital, Providence, RI, USA; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, USA.
Brown University · USButler Hospital · USProvidence College · US

Funding

DEX/CRH Response: Mood/Anxiety Disorder Endophenotype?R01MH068767 · NIMH · BUTLER HOSPITAL (PROVIDENCE, RI) · PI CARPENTER, LINDA L · 2004 to 2013
$3.9M
Promoting Research Training During Psychiatry ResidencyR25MH101076 · NIMH · BROWN UNIVERSITY · PI AUDREY TYRKA · 2013 to 2026
$2.8M
Childhood Maltreatment: Epigenetic Modulation of the Glucocorticoid ReceptorR21MH091508 · NIMH · BUTLER HOSPITAL (PROVIDENCE, RI) · PI TYRKA, AUDREY · 2011 to 2012
$389k
PTSD and the Default Network: Developing Imaging PhenotypesIK2CX000724 · VA · PROVIDENCE VA MEDICAL CENTER · PI PHILIP, NOAH STEPHEN · 2013 to 2017
–
CSRD VA IK2 CX000724NIMH NIH HHS R01 MH068767NIMH NIH HHS R01 MH068767-08S1NIMH NIH HHS R21 MH091508NIMH NIH HHS R25 MH101076
6 · The paper itself

Abstract

Cellular aging plays a role in longevity and senescence, and has been implicated in medical and psychiatric conditions, including heart disease, cancer, major depression and posttraumatic stress disorder. Telomere shortening and mitochondrial dysfunction are thought to be central to the cellular aging process. The present study examined the association between mitochondrial DNA (mtDNA) copy number and telomere length in a sample of medically healthy adults. Participants (total n=392) were divided into 4 groups based on the presence or absence of early life adversity and lifetime psychopathology: No Adversity/No Disorder, n=136; Adversity/No Disorder, n=91; No Adversity/Disorder, n=46; Adversity/Disorder, n=119. Telomere length and mtDNA copy number were measured using quantitative polymerase chain reaction. There was a positive correlation between mtDNA and telomere length in the entire sample (r=0.120, p<0.001) and in each of the four groups of participants (No Adversity/No Disorder, r=0.291, p=0.001; Adversity/No Disorder r=0.279, p=0.007; No Adversity/Disorder r=0.449, p=0.002; Adversity/Disorder, r=0.558, p<0.001). These correlations remained significant when controlling for age, smoking, and body mass index and establish an association between mtDNA and telomere length in a large group of women and men both with and without early adversity and psychopathology, suggesting co-regulation of telomeres and mitochondrial function. The mechanisms underlying this association may be important in the pathophysiology of age-related medical conditions, such as heart disease and cancer, as well as for stress-associated psychiatric disorders.

Indexed as

DNA Copy Number VariationsAdolescentAdultAdult Survivors of Child Adverse EventsAgingBody Mass IndexCellular SenescenceDepressionDNA, MitochondrialFemaleHealthy VolunteersHumansMaleMiddle AgedMitochondriaResidence CharacteristicsDNA, MitochondrialMitochondriaMitochondrial biogenesisMitochondrial DNA copy numberTelomere

Identifiers

PMID25845980
PMCPMC4459604
OpenAlexW1998150842

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.