Evidence map›Paper›PMID 25845881›Full record

ArticleAntimicrobial agents and chemotherapy2015

Etest cannot be recommended for in vitro susceptibility testing of mucorales.

Rita Caramalho, Elisabeth Maurer, Ulrike Binder, Ricardo Araújo, Somayeh Dolatabadi, Cornelia Lass-Flörl, Michaela Lackner

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Pre and Post Covid - 19 Experience of the 'Amphotericin Sandwich' Therapy in the Management of Mucormycosis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Can We Improve Antifungal Susceptibility Testing?Frontiers in cellular and infection microbiology · 2021
    Review
  8. Antifungal Susceptibility Testing: Current Approaches.Clinical microbiology reviews · 2020
    Review
  9. Review
  10. Evaluation of a Novel Mitochondrial Pan-Journal of fungi (Basel, Switzerland) · 2019
    Article
  11. Article
  12. Article
  13. Therapy of Mucormycosis.Journal of fungi (Basel, Switzerland) · 2018
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rita CaramalhoDivision of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Elisabeth MaurerDivision of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Ulrike BinderDivision of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Ricardo AraújoInstitute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal Faculty of Sciences, University of Porto, Porto, Portugal.
Somayeh DolatabadiCBS Fungal Biodiversity Centre, Institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, The Netherlands Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands.
Cornelia Lass-FlörlDivision of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Michaela LacknerDivision of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria Michaela.Lackner@i-med.ac.at.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amphotericin B and posaconazole susceptibility patterns were determined for the most prevalent Mucorales, following EUCAST (European Committee on Antimicrobial Susceptibility Testing) broth microdilution guidelines. In parallel, Etest was performed and evaluated against EUCAST. The overall agreement of MICs gained with Etest and EUCAST was 75.1%; therefore, Etest cannot be recommended for antifungal susceptibility testing of Mucorales. Amphotericin B was the most active drug against Mucorales species in vitro, while the activities of posaconazole were more restricted.

Indexed as

Amphotericin BAntifungal AgentsMicrobial Sensitivity TestsMucoralesAmphotericin BAntifungal Agents

Identifiers

PMID25845881
PMCPMC4432123

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.