Evidence map›Paper›PMID 25845874›Full record

ArticleAntimicrobial agents and chemotherapy2015

Enantiomers of nifurtimox do not exhibit stereoselective anti-Trypanosoma cruzi activity, toxicity, or pharmacokinetic properties.

Carolina B Moraes, Karen L White, Stéphanie Braillard, Catherine Perez, Junghyun Goo, Luis Gaspar, David M Shackleford, Anabela Cordeiro-da-Silva, R C Andrew Thompson, Lucio Freitas-Junior and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Carolina B MoraesCenter for Neglected Diseases Drug Discovery, Institut Pasteur Korea, Bundang-gu, Seongnam-Si, Gyeonggi-do, South Korea.
Karen L WhiteCentre for Drug Candidate Optimisation, Monash University, Parkville, Victoria, Australia.
Stéphanie BraillardDrugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland.
Catherine PerezMurdoch University, Murdoch, WA, Australia.
Junghyun GooCenter for Neglected Diseases Drug Discovery, Institut Pasteur Korea, Bundang-gu, Seongnam-Si, Gyeonggi-do, South Korea.
Luis GasparCenter for Neglected Diseases Drug Discovery, Institut Pasteur Korea, Bundang-gu, Seongnam-Si, Gyeonggi-do, South Korea Faculdade de Farmácia e Instituto de Biologia Molecular Celular da Universidade do Porto, Porto, Portugal.
David M ShacklefordCentre for Drug Candidate Optimisation, Monash University, Parkville, Victoria, Australia.
Anabela Cordeiro-da-SilvaFaculdade de Farmácia e Instituto de Biologia Molecular Celular da Universidade do Porto, Porto, Portugal.
R C Andrew ThompsonMurdoch University, Murdoch, WA, Australia.
Lucio Freitas-JuniorCenter for Neglected Diseases Drug Discovery, Institut Pasteur Korea, Bundang-gu, Seongnam-Si, Gyeonggi-do, South Korea.
Susan A CharmanCentre for Drug Candidate Optimisation, Monash University, Parkville, Victoria, Australia.
Eric ChatelainDrugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland echatelain@dndi.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the aim of improving the available drugs for the treatment of Chagas disease, individual enantiomers of nifurtimox were characterized. The results indicate that the enantiomers are equivalent in their in vitro activity against a panel of Trypanosoma cruzi strains; in vivo efficacy in a murine model of Chagas disease; in vitro toxicity and absorption, distribution, metabolism, and excretion characteristics; and in vivo pharmacokinetic properties. There is unlikely to be any therapeutic benefit of an individual nifurtimox enantiomer over the racemic mixture.

Indexed as

AnimalsChagas DiseaseFemaleHumansMaleMiceNifurtimoxRatsRats, Sprague-DawleyStereoisomerismTrypanocidal AgentsTrypanosoma cruziNifurtimoxTrypanocidal Agents

Identifiers

PMID25845874
PMCPMC4432195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.