ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2015
Asthma and allergy in children with and without prior measles, mumps, and rubella vaccination.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Vaccines for measles, mumps, rubella, and varicella in children.The Cochrane database of systematic reviews · 2021Pooled it
- BCG Vaccination in Early Childhood and Risk of Atopic Disease: A Systematic Review and Meta-Analysis.Canadian respiratory journal · 2021Pooled it
- Vaccines for measles, mumps, rubella, and varicella in children.The Cochrane database of systematic reviews · 2020Pooled it
- Health effects associated with measured contaminants in the Arctic: short communication.International journal of circumpolar health · 2024Article
- The impact of internet health information seeking on COVID-19 vaccination behavior in China.BMC public health · 2024Article
- World Experience in Immunization against Noncommunicable Diseases: Successes and Vectors for Further Development.Vaccines · 2023Article
- Infants' immunisations, their timing and the risk of allergic diseases (INITIAL): an observational prospective cohort study protocol.BMJ open · 2023Article
- When the allergy alarm bells toll: The role of Toll-like receptors in allergic diseases and treatment.Frontiers in molecular biosciences · 2023Review
- The association between adverse reactions and immune response against SARS-CoV-2 spike protein after vaccination with BNT162b2 among healthcare workers in a single healthcare system: a prospective observational cohort study.Human vaccines & immunotherapeutics · 2022Observational
- Clinical form of asthma and vaccine immunity in preschoolers.Postepy dermatologii i alergologii · 2021Article
- The potential of anti-infectives and immunomodulators as therapies for asthma and asthma exacerbations.Allergy · 2018Review
- Association between perfluoroalkyl substance exposure and asthma and allergic disease in children as modified by MMR vaccination.Journal of immunotoxicology · 2017Article
- Shorter duration of breastfeeding at elevated exposures to perfluoroalkyl substances.Reproductive toxicology (Elmsford, N.Y.) · 2017Article
- Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury.International journal of circumpolar health · 2017Article
- Vaccination and Allergic Sensitization in Early Childhood - The ALADDIN Birth Cohort.EClinicalMedicineArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundThe existing literature on the association between measles vaccination and subsequent risk of allergic disease is inconclusive. The aim of this study was, therefore, to determine whether measles, mumps, and rubella (MMR) vaccination administered in early childhood was associated with asthma and allergic diseases at ages 5, 7 and 13 yrs in a birth cohort.
methodsIn the Faroe Islands, 640 children were followed from birth. Follow-up examinations at ages 5, 7 and 13 yrs included a physical examination and a maternal questionnaire about the child's health. At age 7, total and grass-specific IgE was quantified in the child's serum, and at age 13, the children underwent skin prick tests (SPT). The child's vaccination card was reviewed at examinations.
resultsAt age 5, 533 of 555 children had been vaccinated for MMR. After confounder adjustment, we found early life MMR vaccination to be associated with a two-third reduction in the odds of asthma (OR: 0.33, 95% CI: 0.12; 0.90) and hypersensitivity/allergy (OR: 0.32, 95% CI: 0.11; 0.88) at age 5, and the substantially decreased odds of asthma were replicated at age 13 (OR: 0.22, 95% CI: 0.08; 0.56). At age 7, serum total IgE was reduced by 62.8% (CI 95%: -84.3%; -11.9%) in the vaccinated children. MMR vaccination was not significantly associated with allergic rhinoconjuctivitis symptoms, eczema, or SPT reactions at age 13.
conclusionsMMR vaccination early in life may have a protective effect against allergy at least up to age 7 and against asthma through age 13 yrs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.