ArticleThe Journal of comparative neurology2015
Spinal cord neuron inputs to the cuneate nucleus that partially survive dorsal column lesions: A pathway that could contribute to recovery after spinal cord injury.
Article in The Journal of comparative neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Sensory and motor responses after photobiomodulation associated with physiotherapy in patients with incomplete spinal cord injury: clinical, randomized trial.Lasers in medical science · 2020Trial
- Characterizing Evoked Movement Patterns and Connectivity in Sensorimotor Cortex After Sensory Loss in Squirrel Monkeys.The Journal of comparative neurology · 2025Article
- De novo aging-related NADPH diaphorase positive megaloneurites in the sacral spinal cord of aged dogs.Scientific reports · 2023Article
- Regressive changes in sizes of somatosensory cuneate nucleus after sensory loss in primates.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Sensory computations in the cuneate nucleus of macaques.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Cervical cord myelin abnormality is associated with clinical disability in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021Article
- Corticocuneate projections are altered after spinal cord dorsal column lesions in New World monkeys.The Journal of comparative neurology · 2021Article
- Reorganization of Higher-Order Somatosensory Cortex After Sensory Loss from Hand in Squirrel Monkeys.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Cortical Reorganization of Sensorimotor Systems and the Role of Intracortical Circuits After Spinal Cord Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- Second-order spinal cord pathway contributes to cortical responses after long recoveries from dorsal column injury in squirrel monkeys.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Rehabilitation Strategies after Spinal Cord Injury: Inquiry into the Mechanisms of Success and Failure.Journal of neurotrauma · 2017Review
- Relationship between brainstem neurodegeneration and clinical impairment in traumatic spinal cord injury.NeuroImage. Clinical · 2017Article
- Intracortical connections are altered after long-standing deprivation of dorsal column inputs in the hand region of area 3b in squirrel monkeys.The Journal of comparative neurology · 2016Article
- Anatomical changes in the somatosensory system after large sensory loss predict strategies to promote functional recovery after spinal cord injury.Neural regeneration research · 2016Article
- Plasticity and Recovery After Dorsal Column Spinal Cord Injury in Nonhuman Primates.Journal of experimental neuroscience · 2016Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Dorsal column lesions at a high cervical level deprive the cuneate nucleus and much of the somatosensory system of its major cutaneous inputs. Over weeks of recovery, much of the hand representations in the contralateral cortex are reactivated. One possibility for such cortical reactivation by hand afferents is that preserved second-order spinal cord neurons reach the cuneate nucleus through pathways that circumvent the dorsal column lesions, contributing to cortical reactivation in an increasingly effective manner over time. To evaluate this possibility, we first injected anatomical tracers into the cuneate nucleus and plotted the distributions of labeled spinal cord neurons and fibers in control monkeys. Large numbers of neurons in the dorsal horn of the cervical spinal cord were labeled, especially ipsilaterally in lamina IV. Labeled fibers were distributed in the cuneate fasciculus and lateral funiculus. In three other squirrel monkeys, unilateral dorsal column lesions were placed at the cervical segment 4 level and tracers were injected into the ipsilateral cuneate nucleus. Two weeks later, a largely unresponsive hand representation in contralateral somatosensory cortex confirmed the effectiveness of the dorsal column lesion. However, tracer injections in the cuneate nucleus labeled only about 5% of the normal number of dorsal horn neurons, mainly in lamina IV, below the level of lesions. Our results revealed a small second-order pathway to the cuneate nucleus that survives high cervical dorsal column lesions by traveling in the lateral funiculus. This could be important for cortical reactivation by hand afferents, and recovery of hand use.
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