ArticleSleep2015
Cacna1c (Cav1.2) Modulates Electroencephalographic Rhythm and Rapid Eye Movement Sleep Recovery.
Article in Sleep, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Causal relations of trace elements and nutrients with insomnia: A Mendelian randomization study.Medicine · 2025Article
- Voltage Gated Ion Channels and Sleep.The Journal of membrane biology · 2024Review
- Critical periods and Autism Spectrum Disorders, a role for sleep.Neurobiology of sleep and circadian rhythms · 2023Article
- The role of calcium and CaMKII in sleep.Frontiers in systems neuroscience · 2022Review
- Cellular Effects of Rhynchophylline and Relevance to Sleep Regulation.Clocks & sleep · 2021Review
- Sleep Disorders in Children With Autism Spectrum Disorder: Insights From Animal Models, Especially Non-human Primate Model.Frontiers in behavioral neuroscience · 2021Review
- Sleep-Wake Rhythm and Oscillatory Pattern Analysis in a Multiple Hit Schizophrenia Rat Model (Wisket).Frontiers in behavioral neuroscience · 2021Article
- Identification of Gene Loci That Overlap Between Mental Disorders and Poor Prognosis of Cancers.Frontiers in psychiatry · 2021Article
- Sleep, brain development, and autism spectrum disorders: Insights from animal models.Journal of neuroscience research · 2020Review
- Brief Report: A Gene Enrichment Approach Applied to Sleep and Autism.Journal of autism and developmental disorders · 2020Article
- Sleep as a translationally-relevant endpoint in studies of autism spectrum disorder (ASD).Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Williams Syndrome, Human Self-Domestication, and Language Evolution.Frontiers in psychology · 2019Article
- Aetiology of bipolar disorder: contribution of the L-type voltage-gated calcium channels.General psychiatry · 2019Article
- Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood.Molecular psychiatry · 2018Article
- Restoring Serotonergic Homeostasis in the Lateral Hypothalamus Rescues Sleep Disturbances Induced by Early-Life Obesity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Toward the Language Oscillogenome.Frontiers in psychology · 2018Article
- Article
- Variants in calcium voltage-gated channel subunit Alpha1 C-gene (CACNA1C) are associated with sleep latency in infants.PloS one · 2017Article
- Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Bridging the Gap between Genes and Language Deficits in Schizophrenia: An Oscillopathic Approach.Frontiers in human neuroscience · 2016Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesThe CACNA1C gene encodes the alpha 1C (α1C) subunit of the Cav1.2 voltage-dependent L-type calcium channel (LTCC). Some of the other voltage-dependent calcium channels, e.g., P-/Q-type, Cav2.1; N-type, Cav2.2; E-/R-type, Cav2.3; and T-type, Cav3.3 have been implicated in sleep modulation. However, the contribution of LTCCs to sleep remains largely unknown. Based on recent genome-wide association studies, CACNA1C emerged as one of potential candidate genes associated with both sleep and psychiatric disorders. Indeed, most patients with mental illnesses have sleep problems and vice versa.
designTo investigate an impact of Cav1.2 on sleep-wake behavior and electroencephalogram (EEG) activity, polysomnography was performed in heterozygous Cacna1c (HET) knockout mice and their wild-type (WT) littermates under baseline and challenging conditions (acute sleep deprivation and restraint stress). MEASUREMENTS AND
resultsHET mice displayed significantly lower EEG spectral power than WT mice across high frequency ranges (beta to gamma) during wake and rapid eye movement (REM) sleep. Although HET mice spent slightly more time asleep in the dark period, daily amounts of sleep did not differ between the two genotypes. However, recovery sleep after exposure to both types of challenging stress conditions differed markedly; HET mice exhibited reduced REM sleep recovery responses compared to WT mice.
conclusionsThese results suggest the involvement of Cacna1c (Cav1.2) in fast electroencephalogram oscillations and REM sleep regulatory processes. Lower spectral gamma activity, slightly increased sleep demands, and altered REM sleep responses found in heterozygous Cacna1c knockout mice may rather resemble a sleep phenotype observed in schizophrenia patients.
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