ArticleSleep2015
African Genetic Ancestry is Associated with Sleep Depth in Older African Americans.
Article in Sleep, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Trial
- Identifying Risk and Protective Factors for Shift Work Sleep Disorder: Insights from UK Biobank Night Shift Workers.Clocks & sleep · 2025Article
- The Relationship between Sleep and Physical Activity by Age, Race, and Gender.Reviews in cardiovascular medicine · 2024Review
- Obstructive Sleep Apnea and Alzheimer's Disease Pathology: Is Sleep Architecture the Missing Key?Journal of Alzheimer's disease : JAD · 2024Review
- The multidimensionality of sleep in population-based samples: a narrative review.Journal of sleep research · 2022Review
- Racial disparities in adolescent sleep duration: Physical activity as a protective factor.Cultural diversity & ethnic minority psychology · 2021Article
- Sleep Disturbance Predicts Depression Symptoms in Early Adolescence: Initial Findings From the Adolescent Brain Cognitive Development Study.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2020Article
- Do Disparities in Sleep Duration Among Racial and Ethnic Minorities Contribute to Differences in Disease Prevalence?Journal of racial and ethnic health disparities · 2019Review
- Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans.Human molecular genetics · 2019Article
- Sleep and cardiovascular disease: Emerging opportunities for psychology.The American psychologist · 2018Review
- Known genetic susceptibility factors for chronic pancreatitis in patients of European ancestry are rare in patients of African ancestry.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2018Article
- Genetic Ancestry for Sleep Research: Leveraging Health Inequalities to Identify Causal Genetic Variants.Chest · 2018Review
- Cardiovascular Stress Reactivity and Carotid Intima-Media Thickness: The Buffering Role of Slow-Wave Sleep.Psychosomatic medicine · 2018Article
- A Review of the Literature Regarding Sleep and Cardiometabolic Disease in African Descent Populations.Frontiers in endocrinology · 2018Review
- Determinants of racial/ethnic disparities in disordered sleep and obesity.Sleep health · 2017Article
- Place of Birth and Sleep Duration: Analysis of the National Health Interview Survey (NHIS).International journal of environmental research and public health · 2017Article
- The role of race and ethnicity in sleep, circadian rhythms and cardiovascular health.Sleep medicine reviews · 2017Review
- Cytokine polymorphisms are associated with daytime napping in adults living with HIV.Sleep medicine · 2017Article
- Advancing the sleep/wake schedule impacts the sleep of African-Americans more than European-Americans.PloS one · 2017Article
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Authors and funding
7 authors.
Funding
Abstract
STUDY
objectivesThe mechanisms that underlie differences in sleep characteristics between European Americans (EA) and African Americans (AA) are not fully known. Although social and psychological processes that differ by race are possible mediators, the substantial heritability of sleep characteristics also suggests genetic underpinnings of race differences. We hypothesized that racial differences in sleep phenotypes would show an association with objectively measured individual genetic ancestry in AAs.
designCross sectional.
settingCommunity-based study.
participantsSeventy AA adults (mean age 59.5 ± 6.7 y; 62% female) and 101 EAs (mean age 60.5 ± 7 y, 39% female). MEASUREMENTS AND
resultsMultivariate tests were used to compare the Pittsburgh Sleep Quality Index (PSQI) and in-home polysomnographic measures of sleep duration, sleep efficiency, apnea-hypopnea index (AHI), and indices of sleep depth including percent visually scored slow wave sleep (SWS) and delta EEG power of EAs and AAs. Sleep duration, efficiency, and sleep depth differed significantly by race. Individual % African ancestry (%AF) was measured in AA subjects using a panel of 1698 ancestry informative genetic markers and ranged from 10% to 88% (mean 67%). Hierarchical linear regression showed that higher %AF was associated with lower percent SWS in AAs (β (standard error) = -4.6 (1.5); P = 0.002), and explained 11% of the variation in SWS after covariate adjustment. A similar association was observed for delta power. No association was observed for sleep duration and efficiency.
conclusionAfrican genetic ancestry is associated with indices of sleep depth in African Americans. Such an association suggests that part of the racial differences in slow-wave sleep may have genetic underpinnings.
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