ArticleMolecular plant pathology2016
Differential regulation of toxoflavin production and its role in the enhanced virulence of Burkholderia gladioli.
Article in Molecular plant pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 62 citations in OpenAlex.
- The Nitrogen Regulatory Gene ntrC Modulates Virulence and Nitrogen Metabolism in Burkholderia glumae.The plant pathology journal · 2026Article
- Comparative genomic analyses shed light on the introduction routes of rice-pathogenic Burkholderia gladioli strains into Bangladesh.BMC genomics · 2026Article
- Ecological Diversity, Metabolic Versatility, and Biotechnological Applications ofAntibiotics (Basel, Switzerland) · 2025Review
- Genome-Wide Association Study Using High-Density SNP Chip Markers Revealed Novel Bacterial Panicle Blight (Burkholderia glumae) Resistance Genes in Rice.The plant pathology journal · 2025Article
- Ecological Health and Freshwater Pathogen Using eDNA Metabarcoding: A Preliminary Assessment for Environmental Surveillance Development in Malaysia.Microorganisms · 2025Article
- Review
- Distribution and functional analysis of two types of quorum sensing gene pairs, glaI1/glaR1 and glaI2/glaR2, in Burkholderia gladioli.FEMS microbiology letters · 2025Article
- Integrative omics analysis reveals distinct adaptations of bongkrekic acid producingFrontiers in microbiology · 2025Article
- Understanding the Impact of Salt Stress on Plant Pathogens Through Phenotypic and Transcriptomic Analysis.Plants (Basel, Switzerland) · 2025Article
- Bioenergetic suppression by redox-active metabolites promotes antibiotic tolerance inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Identification ofFoods (Basel, Switzerland) · 2024Article
- UnderstandingPlants (Basel, Switzerland) · 2023Article
- Bongkrekic Acid andFoods (Basel, Switzerland) · 2023Review
- Robbsia betulipollinis sp. nov., Isolated from Pollen of Birch (Betula pendula).Current microbiology · 2023Article
- A Bacterial Isolate Capable of Quenching Both Diffusible Signal Factor- andJournal of agricultural and food chemistry · 2022Article
- Phenazines and toxoflavin act as interspecies modulators of resilience to diverse antibiotics.Molecular microbiology · 2022Article
- T6SS Accessory Proteins, Including DUF2169 Domain-Containing Protein and Pentapeptide Repeats Protein, Contribute to Bacterial Virulence in T6SS Group_5 ofPlants (Basel, Switzerland) · 2021Article
- Multimodal Molecular Imaging and Identification of Bacterial Toxins Causing Mushroom Soft Rot and Cavity Disease.Chembiochem : a European journal of chemical biology · 2021Article
- Chemical or Genetic Alteration of Proton Motive Force Results in Loss of Virulence of Burkholderia glumae, the Cause of Rice Bacterial Panicle Blight.Applied and environmental microbiology · 2021Article
- Pan-Genome Analysis Reveals Host-Specific Functional Divergences inMicroorganisms · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Burkholderia gladioli is a causal agent of bacterial panicle blight and sheath/grain browning in rice in many countries. Many strains produce the yellow pigment toxoflavin, which is highly toxic to plants, fungi, animals and microorganisms. Although there have been several studies on the toxoflavin biosynthesis system of B. glumae, it is still unclear how B. gladioli activates toxoflavin biosynthesis. In this study, we explored the genomic organization of the toxoflavin system of B. gladioli and its biological functions using comparative genomic analysis between toxoflavin-producing strains (B. glumae BGR1 and B. gladioli BSR3) and a strain not producing toxoflavin (B. gladioli KACC11889). The latter exhibits normal physiological characteristics similar to other B. gladioli strains. Burkholderia gladioli KACC11889 possesses all the genes involved in toxoflavin biosynthesis, but lacks the quorum-sensing (QS) system that functions as an on/off switch for toxoflavin biosynthesis. These data suggest that B. gladioli has evolved to use the QS signalling cascade of toxoflavin production (TofI/TofR of QS → ToxJ or ToxR → tox operons) similar to that in B. glumae. However, some strains may have evolved to eliminate toxoflavin production through deletion of the QS genes. In addition, we demonstrate that the toxoflavin biosynthetic system enhances the virulence of B. gladioli. These findings provide another line of evidence supporting the differential regulation of the toxoflavin system in Burkholderia strains.
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