Evidence map›Paper›PMID 25845377›Full record

ReviewClinical journal of the American Society of Nephrology : CJASN2015

A brief journey through the immune system.

Karim M Yatim, Fadi G Lakkis

Abstract readReview
In one paragraph

Review in Clinical journal of the American Society of Nephrology : CJASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 2 syntheses or guidelines pooled it, 199 citations in OpenAlex.

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  19. Modulating effects of heat-killed and liveThe veterinary quarterly · 2024
    Article
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Karim M YatimThomas E. Starzl Transplantation Institute and the Departments of Surgery, Immunology, and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Fadi G LakkisThomas E. Starzl Transplantation Institute and the Departments of Surgery, Immunology, and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania lakkisf@upmc.edu.
University of Pittsburgh · US

Funding

T Cell Memory in Organ TransplantationR01AI049466 · NIAID · YALE UNIVERSITY · PI LAKKIS, FADI G. · 2001 to 2024
$7.5M
Innate Recognition of Allogeneic Non-SelfR01AI099465 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LAKKIS, FADI G. · 2012 to 2022
$4.1M
T and B cell Homeostasis After Induction Therapy in Kidney TransplantationR01AI096553 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LAKKIS, FADI G. · 2011 to 2014
$1.4M
NIAID NIH HHS AI049466NIAID NIH HHS AI096553NIAID NIH HHS AI099465NIAID NIH HHS R01 AI049466NIAID NIH HHS R01 AI096553NIAID NIH HHS R01 AI099465
6 · The paper itself

Abstract

This review serves as an introduction to an Immunology Series for the Nephrologist published in CJASN. It provides a brief overview of the immune system, how it works, and why it matters to kidneys. This review describes in broad terms the main divisions of the immune system (innate and adaptive), their cellular and tissue components, and the ways by which they function and are regulated. The story is told through the prism of evolution in order to relay to the reader why the immune system does what it does and why imperfections in the system can lead to renal disease. Detailed descriptions of cell types, molecules, and other immunologic curiosities are avoided as much as possible in an effort to not detract from the importance of the broader concepts that define the immune system and its relationship to the kidney.

Indexed as

Biological EvolutionAdaptive ImmunityAnimalsHumansImmune SystemImmunity, InnateKidneyKidney DiseasesLymphocytesLymphoid TissueARFGNimmunologyrenal transplantationtolerance

Identifiers

PMID25845377
PMCPMC4491295
OpenAlexW2143540084

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.