Evidence map›Paper›PMID 25845339›Full record

ReviewMolecular carcinogenesis2015

Impact of dietary components on NK and Treg cell function for cancer prevention.

Young S Kim, Thomas J Sayers, Nancy H Colburn, John A Milner, Howard A Young

2 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in Molecular carcinogenesis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05432362 narecruitingnot on this mapstarted 2019, after this paper: background citation

ESAN II - Energy Sensing in Depression. Effects of Aronia Melanocarpa on Immunomodulation in Patients With Obesity, Depression, and Normal Weight Controls.

TypeinterventionalSponsorMedical University of GrazRan2019 to 2026Enrolled120ConditionsImmune System Tolerance, Depression, Obesity, Microbial ColonizationArmsAronia Juice, Placebo
NCT06985381 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

ESAN III - Energy Sensing in Depression Effects of Daucus Carota Subsp. Sativus on Immunomodulation in Patients With Obesity, Depression, and Normal Weight Controls

TypeinterventionalSponsorMedical University of GrazRan2024 to 2026Enrolled120ConditionsObesity, Gut Microbiota Modulation, ImmunomodulationArmsCarotenoid-rich juice, Control
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Discovery of cancer-preventive juices reactivating RB functions.Environmental health and preventive medicine · 2023
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Young S KimNutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, Maryland.
Thomas J SayersFrederick National Laboratory, Center for Cancer Research, NCI, Frederick, Maryland.
Nancy H ColburnFrederick National Laboratory, Center for Cancer Research, NCI, Frederick, Maryland.
John A MilnerHuman Nutrition Research Center, USDA/ARS, Beltsville, Maryland.
Howard A YoungFrederick National Laboratory, Center for Cancer Research, NCI, Frederick, Maryland.
Frederick National Laboratory for Cancer Research · USBeltsville Human Nutrition Research Center · USNational Cancer Institute · US

Funding

Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

An important characteristic of cancer is that the disease can overcome the surveillance of the immune system. A possible explanation for this resistance arises from the ability of tumor cells to block the tumoricidal activity of host immune cells such as natural killer (NK) cells by inducing the localized accumulation of regulatory T (Treg) cells. Evidence exists that components in commonly consumed foods including vitamins A, D, and E, water-soluble constituents of mushrooms, polyphenolics in fruits and vegetables, and n-3 fatty acids in fish oil can modulate NK cell activities, Treg cell properties, and the interactions between those two cell types. Thus, it is extremely important for cancer prevention to understand the involvement of dietary components with the early stage dynamics of interactions among these immune cells. This review addresses the potential significance of diet in supporting the function of NK cells, Treg cells, and the balance between those two cell types, which ultimately results in decreased cancer risk.

Indexed as

DietAnimalsCytokinesFatty Acids, Omega-3HumansKiller Cells, NaturalNeoplasmsPolyphenolsT-Lymphocytes, RegulatoryVitamin AVitamin DCytokinesFatty Acids, Omega-3PolyphenolsVitamin AVitamin Dcancer preventiondietary componentsnatural killer cellsregulatory t cells

Identifiers

PMID25845339
PMCPMC4536099
OpenAlexW2104543894

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.