ArticlePloS one2015
Minimal conductance-based model of auditory coincidence detector neurons.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Article
- Association of resistome abundance with hyperuricaemia in elderly individuals: a metagenomics study.Frontiers in microbiomes · 2024Article
- Soma-axon coupling configurations that enhance neuronal coincidence detection.PLoS computational biology · 2019Article
- Physiological models of the lateral superior olive.PLoS computational biology · 2017Article
- Tonotopic Optimization for Temporal Processing in the Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sound localization is a fundamental sensory function of a wide variety of animals. The interaural time difference (ITD), an important cue for sound localization, is computed in the auditory brainstem. In our previous modeling study, we introduced a two-compartment Hodgkin-Huxley type model to investigate how cellular and synaptic specializations may contribute to precise ITD computation of the barn owl's auditory coincidence detector neuron. Although our model successfully reproduced fundamental physiological properties observed in vivo, it was unsuitable for mathematical analyses and large scale simulations because of a number of nonlinear variables. In the present study, we reduce our former model into three types of conductance-based integrate-and-fire (IF) models. We test their electrophysiological properties using data from published in vivo and in vitro studies. Their robustness to parameter changes and computational efficiencies are also examined. Our numerical results suggest that the single-compartment active IF model is superior to other reduced models in terms of physiological reproducibility and computational performance. This model will allow future theoretical studies that use more rigorous mathematical analysis and network simulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.