Evidence map›Paper›PMID 25844763›Full record

ArticleThe Journal of clinical endocrinology and metabolism2015

Commentary: Launch of a quality improvement network for evidence-based management of uncommon pediatric endocrine disorders: Turner syndrome as a prototype.

Robert L Rosenfield, Linda A DiMeglio, Nelly Mauras, Judith Ross, Natalie D Shaw, Siri A W Greeley, Morey Haymond, Karen Rubin, Erinn T Rhodes

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Diagnostic and therapeutic considerations in Turner syndrome.Annals of pediatric endocrinology & metabolism · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 1 country.

Robert L RosenfieldSection of Adult and Pediatric Endocrinology, Diabetes, and Metabolism (R.L.R., S.A.W.G.), The University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637; Department of Pediatrics (L.A.D.), Indiana University School of Medicine, Indianapolis, Indiana 46202; Division of Endocrinology, Diabetes, and Metabolism (N.M.), Nemours Children's Clinic, Jacksonville, Florida 32207; Department of Pediatrics (J.R.), Jefferson University, Philadelphia, Pennsylvania 19107; Nemours/duPont Hospital for Children (J.R.), Wilmington, Delaware 19803; Reproductive Endocrine Unit (N.D.S.), Massachusetts General Hospital, Boston, Massachusetts 02114; Division of Endocrinology (N.D.S., E.T.R.), Boston Children's Hospital, Boston, Massachusetts 02115; Department of Pediatrics (M.H.), Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas 77030; Connecticut Children's Medical Center (K.R.), Hartford, Connecticut 06106; and University of Connecticut School of Medicine (K.R.), Farmington, Connecticut 06032.
Linda A DiMeglio
Nelly Mauras
Judith Ross
Natalie D Shaw
Siri A W Greeley
Morey Haymond
Karen Rubin
Erinn T Rhodes
University of Chicago · USBoston Children's Hospital · USChildren's Nutrition Research Center at Baylor College of Medicine · USCommunity Health Systems - Dupont Hospital · USIndiana University – Purdue University Indianapolis · USMassachusetts General Hospital · USNemours Children's Clinic · USUniversity of Connecticut · US

Funding

Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI RONALD N COHEN · 2013 to 2026
$20.9M
Incretin Regulation of Insulin Secretion in Human Neonatal DiabetesK23DK094866 · NIDDK · UNIVERSITY OF CHICAGO · PI GREELEY, SIRI ATMA W. · 2012 to 2014
$515k
NIDDK NIH HHS K23 DK094866NIDDK NIH HHS P30 DK020595
6 · The paper itself

Abstract

backgroundTraditional, hypothesis-oriented research approaches have thus far failed to generate sufficient evidence to achieve consensus about the management of children with many endocrine disorders, partly because of the rarity of these disorders and because of regulatory burdens unique to research in children.

objectiveThe Pediatric Endocrine Society is launching a quality improvement network in spring 2015 for the management of pediatric endocrine disorders that are relatively uncommon in any single practice and/or for which there is no consensus on management.

designThe first of the quality improvement programs to be implemented seeks to improve the care of 11- to 17-year-old girls with Turner syndrome who require initiation of estrogen replacement therapy by providing a standardized clinical assessment and management plan (SCAMP) for transdermal estradiol treatment to induce pubertal development. The SCAMP algorithm represents a starting point within current best practice that is meant to undergo refinement through an iterative process of analysis of deidentified data collected in the course of clinical care by a network of pediatric endocrinologists.

conclusionIt is anticipated that this program will not only improve care, but will also result in actionable data that will generate new research hypotheses and changes in management of pediatric endocrine disorders.

Indexed as

Community NetworksEvidence-Based PracticeQuality ImprovementAdolescentAlgorithmsChildEndocrine System DiseasesEstrogen Replacement TherapyFemaleHumansRare DiseasesResearch DesignTurner Syndrome

Identifiers

PMID25844763
PMCPMC5393512
OpenAlexW2171889718

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.