ArticleCellular and molecular gastroenterology and hepatology2015
Enteric neuron imbalance and proximal dysmotility in ganglionated intestine of the
Article in Cellular and molecular gastroenterology and hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Morphological evidence suggestive of a hierarchical mode of glial cell diversification and intrinsic developmental plasticity within the murine enteric nervous system.Frontiers in neuroscience · 2025Article
- Deciphering the complexity of enteric niches in Hirschsprung disease: from metaphorical insights to therapeutic transformation.Frontiers in pediatrics · 2025Review
- Current and future state of the management of Hirschsprung disease.World journal of pediatric surgery · 2025Review
- West Nile virus triggers intestinal dysmotility via T cell-mediated enteric nervous system injury.The Journal of clinical investigation · 2024Article
- Circular RNA MTCL1 targets SMAD3 by sponging miR-145-5p for regulation of cell proliferation and migration in Hirschsprung's disease.Pediatric surgery international · 2023Article
- Dscam1 overexpression impairs the function of the gut nervous system in Drosophila.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Modification of Neurogenic Colonic Motor Behaviours by Chemogenetic Ablation of Calretinin Neurons.Frontiers in cellular neuroscience · 2022Article
- Unique Neural Circuit Connectivity of Mouse Proximal, Middle, and Distal Colon Defines Regional Colonic Motor Patterns.Cellular and molecular gastroenterology and hepatology · 2022Article
- Article
- Pan-enteric neuropathy and dysmotility are present in a mouse model of short-segment Hirschsprung disease and may contribute to post-pullthrough morbidity.Journal of pediatric surgery · 2021Article
- Analysis of enteric nervous system and intestinal epithelial barrier to predict complications in Hirschsprung's disease.Scientific reports · 2020Article
- Dlx1/2 mice have abnormal enteric nervous system function.JCI insight · 2020Article
- Down syndrome mouse models have an abnormal enteric nervous system.JCI insight · 2019Article
- Gut microbiota-mediated Gene-Environment interaction in the TashT mouse model of Hirschsprung disease.Scientific reports · 2019Article
- Enteric nervous system development: what could possibly go wrong?Nature reviews. Neuroscience · 2018Review
- Medial preoptic circuit induces hunting-like actions to target objects and prey.Nature neuroscience · 2018Article
- Hirschsprung disease - integrating basic science and clinical medicine to improve outcomes.Nature reviews. Gastroenterology & hepatology · 2018Review
- Colitis promotes neuronal differentiation of Sox2+ and PLP1+ enteric cells.Scientific reports · 2017Article
- Arundic Acid Prevents Developmental Upregulation of S100B Expression and Inhibits Enteric Glial Development.Frontiers in cellular neuroscience · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND &
aimsIn Hirschsprung disease (HSCR), neural crest-derived progenitors (NCPs) fail to completely colonize the intestine so that the enteric nervous system (ENS) is absent from distal bowel. Despite removal of the aganglionic region, many HSCR patients suffer from residual intestinal dysmotility. To test the hypothesis that inappropriate lineage segregation of NCPs in proximal ganglionated regions of the bowel could contribute to such postoperative disease, we investigated neural crest (NC)-derived lineages and motility in ganglionated, postnatal intestine of the
methodsCre-mediated fate-mapping was applied to evaluate relative proportions of NC-derived cell types. Motility assays were performed to assess gastric emptying and small intestine motility while colonic inflammation was assessed by histopathology for
results
conclusionsThe
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.