ArticleNeuroImage. Clinical2015
T2 mapping outperforms normalised FLAIR in identifying hippocampal sclerosis.
Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Differentiation of multiple brain metastases and glioblastoma with multiple foci using MRI criteria.BMC medical imaging · 2024Article
- Combined quantitative T2 mapping and [European radiology · 2022Article
- Efficient phase-cycling strategy for high-resolution 3D gradient-echo quantitative parameter mapping.NMR in biomedicine · 2022Article
- A quantitative MRI index for assessing the severity of hippocampal sclerosis in temporal lobe epilepsy.BMC medical imaging · 2020Article
- Hippocampal Sclerosis Detection with NeuroQuant Compared with Neuroradiologists.AJNR. American journal of neuroradiology · 2020Article
- Article
- Towards in vivo focal cortical dysplasia phenotyping using quantitative MRI.NeuroImage. Clinical · 2017Review
- Brain imaging in the assessment for epilepsy surgery.The Lancet. Neurology · 2016Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleQualitatively, FLAIR MR imaging is sensitive to the detection of hippocampal sclerosis (HS). Quantitative analysis of T2 maps provides a useful objective measure and increased sensitivity over visual inspection of T2-weighted scans. We aimed to determine whether quantification of normalised FLAIR is as sensitive as T2 mapping in detection of HS.
methodDual echo T2 and FLAIR MR images were retrospectively analysed in 27 patients with histologically confirmed HS and increased T2 signal in ipsilateral hippocampus and 14 healthy controls. Regions of interest were manually segmented in all hippocampi aiming to avoid inclusion of CSF. Hippocampal T2 values and measures of normalised FLAIR Signal Intensity (nFSI) were compared in healthy and sclerotic hippocampi.
resultsHS was identified on T2 values with 100% sensitivity and 100% specificity. HS was identified on nFSI measures with 60% sensitivity and 93% specificity.
conclusionT2 mapping is superior to nFSI for identification of HS.
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