ArticleInterface focus2015
Multiscale modelling of the feto-placental vasculature.
Article in Interface focus, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- A Review of Biomechanics Analysis of the Umbilical-Placenta System With Regards to Diseases.Frontiers in physiology · 2021Pooled it
- Multiscale computational modeling to quantify how spiral artery remodeling alters wall shear stress on placental villi.PLoS computational biology · 2026Article
- Article
- Influence of arteries, vein and placenta interactions on the blood flow in the human umbilical cord.PloS one · 2026Article
- A functional shunt in the umbilical cord: the role of coiling in solute and heat transfer.Journal of the Royal Society, Interface · 2025Article
- In vitro examination of Piezo1-TRPV4 dynamics: implications for placental endothelial function in normal and preeclamptic pregnancies.American journal of physiology. Cell physiology · 2025Article
- A flexible generative algorithm for growing in silico placentas.PLoS computational biology · 2024Article
- Unveiling the human fetal-maternal interface during the first trimester: biophysical knowledge and gaps.Frontiers in cell and developmental biology · 2024Review
- Flow in fetoplacental-like microvessels in vitro enhances perfusion, barrier function, and matrix stability.Science advances · 2023Article
- A review of feto-placental vasculature flow modelling.Placenta · 2023Review
- Peripheral cord insertion is associated with adverse pregnancy outcome only when accompanied by clinically significant placental pathology.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2023Article
- Developments in functional imaging of the placenta.The British journal of radiology · 2023Review
- Multi-scale Modelling of Shear Stress on the Syncytiotrophoblast: Could Maternal Blood Flow Impact Placental Function Across Gestation?Annals of biomedical engineering · 2023Article
- Personalising cardiovascular network models in pregnancy: A two-tiered parameter estimation approach.International journal for numerical methods in biomedical engineering · 2021Article
- Review
- The Role of the 3Rs for Understanding and Modeling the Human Placenta.Journal of clinical medicine · 2021Review
- Bioengineering Approaches for Placental Research.Annals of biomedical engineering · 2021Review
- Structure-function relationships in the feto-placental circulation from in silico interpretation of micro-CT vascular structures.Journal of theoretical biology · 2021Article
- Article
- Differences in placental capillary shear stress in fetal growth restriction may affect endothelial cell function and vascular network formation.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The placenta provides all the nutrients required for the fetus through pregnancy. It develops dynamically, and, to avoid rejection of the fetus, there is no mixing of fetal and maternal blood; rather, the branched placental villi 'bathe' in blood supplied from the uterine arteries. Within the villi, the feto-placental vasculature also develops a complex branching structure in order to maximize exchange between the placental and maternal circulations. To understand the development of the placenta, we must translate functional information across spatial scales including the interaction between macro- and micro-scale haemodynamics and account for the effects of a dynamically and rapidly changing structure through the time course of pregnancy. Here, we present steps towards an anatomically based and multiscale approach to modelling the feto-placental circulation. We assess the effect of the location of cord insertion on feto-placental blood flow resistance and flow heterogeneity and show that, although cord insertion does not appear to directly influence feto-placental resistance, the heterogeneity of flow in the placenta is predicted to increase from a 19.4% coefficient of variation with central cord insertion to 23.3% when the cord is inserted 2 cm from the edge of the placenta. Model geometries with spheroidal and ellipsoidal shapes, but the same volume, showed no significant differences in flow resistance or heterogeneity, implying that normal asymmetry in shape does not affect placental efficiency. However, the size and number of small capillary vessels is predicted to have a large effect on feto-placental resistance and flow heterogeneity. Using this new model as an example, we highlight the importance of taking an integrated multi-disciplinary and multiscale approach to understand development of the placenta.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.