ArticleNew journal of physics2015
Emerging of fractal geometry on surface of human cervical epithelial cells during progression towards cancer.
Article in New journal of physics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 61 citations in OpenAlex.
- Review
- Detection of Human Bladder Epithelial Cancerous Cells with Atomic Force Microscopy and Machine Learning.Cells · 2024Article
- On machine learning analysis of atomic force microscopy images for image classification, sample surface recognition.Physical chemistry chemical physics : PCCP · 2024Review
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- Nanoscale Prognosis of Colorectal Cancer Metastasis from AFM Image Processing of Histological Sections.Cancers · 2023Article
- Article
- The Fractal Viewpoint of Tumors and Nanoparticles.Current medicinal chemistry · 2023Review
- The Sub-Molecular and Atomic Theory of Cancer Beginning: The Role of Mitochondria.Diagnostics (Basel, Switzerland) · 2022Article
- Acceleration of imaging in atomic force microscopy working in sub-resonance tapping mode.The Review of scientific instruments · 2022Article
- Difference in biophysical properties of cancer-initiating cells in melanoma mutated zebrafish.Journal of the mechanical behavior of biomedical materials · 2020Article
- Article
- Nanoscale compositional mapping of cells, tissues, and polymers with ringing mode of atomic force microscopy.Scientific reports · 2017Article
- Analysis of the shapes of coelomocytes of Aphelasterias japonica in vitro (Echinodermata: Asteroidea).Protoplasma · 2017Article
- An Emergence Framework of Carcinogenesis.Frontiers in oncology · 2017Article
- An Abraded Surface of Doxorubicin-Loaded Surfactant-Containing Drug Delivery Systems Effectively Reduces the Survival of Carcinoma Cells.Biomedicines · 2016Article
- Towards early detection of cervical cancer: Fractal dimension of AFM images of human cervical epithelial cells at different stages of progression to cancer.Nanomedicine : nanotechnology, biology, and medicine · 2015Article
- Intercellular Signaling in Cancer-the SMT and TOFT Hypotheses, Exosomes, Telocytes and Metastases: Is the Messenger in the Message?Journal of Cancer · 2015Review
- Subtle Immunoreactivity Differences in the Fractal Patterns of Membrane E-Cadherin in Gastric Adenocarcinoma.Current health sciences journalArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Despite considerable advances in understanding the molecular nature of cancer, many biophysical aspects of malignant development are still unclear. Here we study physical alterations of the surface of human cervical epithelial cells during stepwise in vitro development of cancer (from normal to immortal (premalignant), to malignant). We use atomic force microscopy to demonstrate that development of cancer is associated with emergence of simple fractal geometry on the cell surface. Contrary to the previously expected correlation between cancer and fractals, we find that fractal geometry occurs only at a limited period of development when immortal cells become cancerous; further cancer progression demonstrates deviation from fractal. Because of the connection between fractal behaviour and chaos (or far from equilibrium behaviour), these results suggest that chaotic behaviour coincides with the cancer transformation of the immortalization stage of cancer development, whereas further cancer progression recovers determinism of processes responsible for cell surface formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.