Evidence map›Paper›PMID 25844041›Full record

ArticleGastrointestinal cancer : targets and therapy2015

Von Hippel-Lindau status influences phenotype of liver cancers arising from PTEN loss.

Adam B Sendor, Kathryn E Hacker, Shufen Chen, Armando L Corona, Oishee Sen, Derek Y Chiang, Anna Snavely, Arlin B Rogers, Stephanie A Montgomery, W Kimryn Rathmell and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Gastrointestinal cancer : targets and therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Adam B SendorLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Kathryn E HackerLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Shufen ChenLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Armando L CoronaLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Oishee SenLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Derek Y ChiangLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Anna SnavelyLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Arlin B RogersSection of Pathology, Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, Boston, MA, USA.
Stephanie A MontgomeryLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
W Kimryn RathmellLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Autumn J McReeLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
UNC Lineberger Comprehensive Cancer CenterUniversity of North Carolina at Chapel Hill · USTufts University · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008719 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DARVILLE, TONI, DESHMUKH, MOHANISH P · 1999 to 2023
$15.1M
UNC Oncology K12K12CA120780 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WILLIAM Y. KIM · 2007 to 2026
$9.6M
UNC PREP in the Biomedical Sciences - Administrative SupplementR25GM089569 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBINSON, DONITA L, RODRIGUEZ-ROMAGUERA, JOSE · 2010 to 2024
$5.6M
Genetic Events in the Development of Renal Cell CarcinomaR01CA121781 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RATHMELL, WENDY KIMRYN · 2007 to 2011
$1.4M
Enhancing Translational Science via Prospective InvestigationK24CA172355 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RATHMELL, WENDY KIMRYN · 2013 to 2017
$870k
NCI NIH HHS K12 CA120780NCI NIH HHS K24 CA172355NCI NIH HHS P30 CA016086NCI NIH HHS R01 CA121781NIEHS NIH HHS P30 ES010126NIGMS NIH HHS R25 GM089569NIGMS NIH HHS T32 GM008719
6 · The paper itself

Abstract

background

methodsWe used a CreER-linked Keratin 18 mouse model to conditionally delete

resultsBoth

conclusion

Indexed as

cholangiocarcinoma (CC)hepatocellular-cholangiocarcinoma (HCC)phosphatase and tension homologue deleted on chromosome 10 (PTEN)Von Hippel-Lindau (VHL)

Identifiers

PMID25844041
PMCPMC4383253
OpenAlexW1986834864

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.