Evidence map›Paper›PMID 25844035›Full record

ArticleInternational journal of nanomedicine2015

Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast.

Francisco G Ortega, Martín A Fernández-Baldo, Jorge G Fernández, María J Serrano, María I Sanz, Juan J Diaz-Mochón, José A Lorente, Julio Raba

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Eco-Friendly Greener Synthesis of Nanoparticles.Advanced pharmaceutical bulletin · 2020
    Review
  12. Review
  13. Article
  14. A Current Overview of the Biological and Cellular Effects of Nanosilver.International journal of molecular sciences · 2018
    Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Extremophiles as sources of inorganic bio-nanoparticles.World journal of microbiology & biotechnology · 2016
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Francisco G OrtegaGENYO, Centre for Genomics and Oncological Research: Pfizer-University of Granada, Andalusian Regional Government, PTS Granada, Avenida de Ilustración, Granada, Spain.
Martín A Fernández-BaldoINQUISAL, Departamento de Química, CONICET, Universidad Nacional de San Luis, San Luis, Argentina.
Jorge G FernándezINQUISAL, Departamento de Química, CONICET, Universidad Nacional de San Luis, San Luis, Argentina.
María J SerranoGENYO, Centre for Genomics and Oncological Research: Pfizer-University of Granada, Andalusian Regional Government, PTS Granada, Avenida de Ilustración, Granada, Spain.
María I SanzINQUISAL, Departamento de Química, CONICET, Universidad Nacional de San Luis, San Luis, Argentina.
Juan J Diaz-MochónGENYO, Centre for Genomics and Oncological Research: Pfizer-University of Granada, Andalusian Regional Government, PTS Granada, Avenida de Ilustración, Granada, Spain.
José A LorenteGENYO, Centre for Genomics and Oncological Research: Pfizer-University of Granada, Andalusian Regional Government, PTS Granada, Avenida de Ilustración, Granada, Spain.
Julio RabaINQUISAL, Departamento de Química, CONICET, Universidad Nacional de San Luis, San Luis, Argentina.
Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present article, we describe a study of antitumor activity in breast cell lines using silver nanoparticles (Ag NPs) synthesized by a microbiological method. These Ag NPs were tested for their antitumor activity against MCF7 and T47D cancer cells and MCF10-A normal breast cell line. We analyzed cell viability, apoptosis induction, and endocytosis activity of those cell lines and we observed that the effects of the biosynthesized Ag NPs were directly related with the endocytosis activity. Moreover, Ag NPs had higher inhibition efficacy in tumor lines than in normal lines of breast cells, which is due to the higher endocytic activity of tumor cells compared to normal cells. In this way, we demonstrate that biosynthesized Ag NPs can be an alternative for the treatment of tumors.

Indexed as

Metal NanoparticlesAntineoplastic AgentsApoptosisBiotechnologyBreast NeoplasmsCell LineCell SurvivalCryptococcusDrug Screening Assays, AntitumorEndocytosisFemaleHumansMCF-7 CellsMicroscopy, FluorescenceSilverAntineoplastic AgentsSilverapoptosisbiosynthesized silver nanoparticlesbreast cancermicrobiological synthesis

Identifiers

PMID25844035
PMCPMC4368032
OpenAlexW2095702737

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.