ArticleAppetite2015
Obesity, fitness, and brain integrity in adolescence.
Article in Appetite, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Brain structural and functional changes in childhood and adolescent obesity: a systematic review of MRI studies.Frontiers in human neuroscience · 2026Pooled it
- Executive and Reward-Related Function in Pediatric Obesity: A Meta-Analysis.Childhood obesity (Print) · 2018Pooled it
- Higher VOScientific reports · 2021Trial
- Sleep, Physical Activity, and Executive Functions in Students: A Narrative Review.Clocks & sleep · 2025Review
- The Effects of Single-Bout Exercise Interventions with Different Exercise Modalities on Executive Function in Youths.Sports (Basel, Switzerland) · 2024Article
- The relationship in early childhood body composition and physical activity levels regarding fundamental motor skill development.BMC pediatrics · 2023Article
- Relationships between physical activity, healthy eating and cortical thickness in children and young adults.Brain imaging and behavior · 2022Article
- The Developing Brain: Considering the Multifactorial Effects of Obesity, Physical Activity & Mental Wellbeing in Childhood and Adolescence.Children (Basel, Switzerland) · 2022Review
- Abnormalities in deep-brain morphology and orbitofrontal cortical thinning relate to reward processing and body mass in adolescent girls.International journal of obesity (2005) · 2022Article
- Does obesity-associated insulin resistance affect brain structure and function of adolescents differentially by sex?Psychiatry research. Neuroimaging · 2022Article
- The Combined Effects of Obesity and Cardiorespiratory Fitness Are Associated with Response Inhibition: An ERP Study.International journal of environmental research and public health · 2021Article
- Cardiorespiratory and muscular fitness associations with older adolescent cognitive control.Journal of sport and health science · 2021Article
- Objective aerobic fitness level and neuropsychological functioning in healthy adolescents and emerging adults: Unique sex effects.Psychology of sport and exercise · 2020Article
- Inflammatory agents partially explain associations between cortical thickness, surface area, and body mass in adolescents and young adulthood.International journal of obesity (2005) · 2020Article
- Childhood Obesity, Cortical Structure, and Executive Function in Healthy Children.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Prefrontal Cortex and Amygdala Subregion Morphology Are Associated With Obesity and Dietary Self-control in Children and Adolescents.Frontiers in human neuroscience · 2020Article
- A hypothesis linking the energy demand of the brain to obesity risk.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Pituitary Gland Functional Connectivity and BMI.Frontiers in neuroscience · 2019Article
- Greater body mass index is associated with reduced frontal cortical volumes among adolescents with bipolar disorder.Journal of psychiatry & neuroscience : JPN · 2018Article
- Exercise, cognition, and the adolescent brain.Birth defects research · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe set out to ascertain the relationship between insulin resistance, fitness, and brain structure and function in adolescents. DESIGN AND
methodsWe studied 79 obese and 51 non-obese participants who were recruited from the community, all without type 2 diabetes mellitus. All participants received medical, endocrine, neuropsychological, and MRI evaluations as well as a 6-minute walk test that was used to estimate fitness (maximal oxygen consumption).
resultsObese adolescents had significantly thinner orbitofrontal cortices and performed significantly worse on Visual Working Memory tasks and the Digit Vigilance task. Insulin sensitivity and maximal oxygen consumption (VO2 max) were both highly correlated with central obesity and orbitofrontal cortical thickness, although insulin sensitivity was the stronger predictor for orbitofrontal cortical thickness. We also found that VO2 max was the only significant physiological variable related to visual working memory.
conclusionsThis is the first study to report positive associations between insulin resistance, VO2 max, and frontal lobe brain integrity in adolescents. Given the importance of brain health for learning and school performance, we conclude that schools should also emphasize physical fitness in order to maintain structural and functional brain integrity and facilitate academic achievement.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.