Evidence map›Paper›PMID 25843799›Full record

ArticleBiochemical and biophysical research communications2015

RIG-I-dependent antiviral immunity is effective against an RNA virus encoding a potent suppressor of RNAi.

Xiaoxu Fan, Shuwei Dong, Yang Li, Shou-wei Ding, Ming Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Nucleic Acid Immunity.Advances in immunology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Xiaoxu FanKey Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China; Department of Plant Pathology and Microbiology, and Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA.
Shuwei DongDepartment of Plant Pathology and Microbiology, and Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA; State Key Laboratory for Agrobiotechnology and Ministry of Agriculture, Key Laboratory for Plant Pathology, China Agricultural University, Beijing 100193, China.
Yang LiDepartment of Plant Pathology and Microbiology, and Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA.
Shou-wei DingDepartment of Plant Pathology and Microbiology, and Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA. Electronic address: shou-wei.ding@ucr.edu.
Ming WangKey Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China; Key Laboratory of Veterinary Bioproduction and Veterinary Medicine of the Ministry of Agriculture, Zhongmu Institute of China Animal Husbandry Industry Co., Ltd, No. 156 Beiqing Road, Haidian District, Beijing 100095, China. Electronic address: vetdean@cau.edu.cn.
China Agricultural University · CNUniversity of California, Riverside · USMinistry of Agriculture · ID

Funding

Gene Silencing as an Antiviral Defense in Animal CellsR01AI052447 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI DING, SHOU-WEI · 2003 to 2016
$6.0M
NIAID NIH HHS AI52447NIAID NIH HHS R01 AI052447
6 · The paper itself

Abstract

Nodamura virus (NoV) lethally infects suckling mice and contains a segmented positive-strand RNA genome that encodes a potent suppressor of RNA interference (RNAi). Recent studies have demonstrated immune detection and subsequent processing of NoV dsRNA replicative intermediates by the mouse RNAi machinery. However, diverse RNA viruses, including Encephalomyocarditis virus that also triggers Dicer-dependent biogenesis of viral siRNAs in mouse cells, are targeted in mammals by RIG-I-like receptors that initiate an IFN-dependent antiviral response. Using mouse embryonic fibroblasts (MEFs) for NoV infection, here we show that MEFs derived from mice knockout for RIG-I, but not those knockout for MDA5, LGP2, TLR3 or TLR7, exhibited an enhanced susceptibility to NoV. Further studies indicate that NoV infection induced an IFN-dependent antiviral response mediated by RIG-I. Our findings suggest that RIG-I directs a typical IFN-dependent antiviral response against an RNA virus capable of suppressing the RNAi response.

Indexed as

RNA InterferenceAnimalsBase SequenceCells, CulturedDEAD Box Protein 58DEAD-box RNA HelicasesDNA PrimersDrug Resistance, ViralInterferon-betaMiceMice, Inbred BALB CMice, KnockoutReal-Time Polymerase Chain ReactionRNA VirusesDdx58 protein, mouseDEAD Box Protein 58DEAD-box RNA HelicasesDNA PrimersInterferon-betaNoVRIG-IRNAiType I interferons

Identifiers

PMID25843799
PMCPMC4426002
OpenAlexW1989631863

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.