ArticleNeuron2015
Inhibitory and excitatory spike-timing-dependent plasticity in the auditory cortex.
Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
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Who cites it
107 citing papers in PubMed.
- Effects of spatial constraints of inhibitory connectivity on the dynamical development of criticality in spiking networks.PLoS computational biology · 2026Article
- Synaptic-state-dependent plasticity routes learning signals in recurrent circuits.bioRxiv : the preprint server for biology · 2026Article
- Cell-Type-Specific Synaptic Scaling Mechanisms Differentially Contribute to Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Homeostatic Plasticity Enables Stable yet Tunable Neuronal Assemblies.bioRxiv : the preprint server for biology · 2026Article
- Inhibitory-stabilization is sufficient for history-dependent computation in a randomly connected attractor network.Journal of computational neuroscience · 2026Article
- Timing and Convergence of Ensemble Activity Govern Auditory Thalamocortical Transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Emergence of sparse coding, balance and decorrelation from a biologically-grounded spiking neural network model of learning in the primary visual cortex.PLoS computational biology · 2025Article
- Correctness is its own reward: bootstrapping error signals in self-guided reinforcement learning.bioRxiv : the preprint server for biology · 2025Article
- Heterogeneous synaptic homeostasis: A novel mechanism boosting information propagation in the cortex.PLoS computational biology · 2025Article
- Embedding stochastic dynamics of the environment in spontaneous activity by prediction-based plasticity.eLife · 2025Article
- Article
- Balancing complexity, performance and plausibility to meta learn plasticity rules in recurrent spiking networks.PLoS computational biology · 2025Article
- Amplifying post-stimulation oscillatory dynamics by engaging synaptic plasticity with transcranial alternating current stimulation.Frontiers in network physiology · 2025Article
- Modulating excitation/inhibition balance through transcranial electrical stimulation: physiological mechanisms in animal models.Frontiers in neuroscience · 2025Review
- Autonomous retrieval for continuous learning in associative memory networks.Frontiers in computational neuroscience · 2025Article
- Inhibitory plasticity supports replay generalization in the hippocampus.Nature neuroscience · 2024Article
- Input specificity of NMDA-dependent GABAergic plasticity in the hippocampus.Scientific reports · 2024Article
- Learning, Fast and Slow: Single- and Many-Shot Learning in the Hippocampus.Annual review of neuroscience · 2024Review
- Contributions of cortical neuron firing patterns, synaptic connectivity, and plasticity to task performance.Nature communications · 2024Article
- Synapse-type-specific competitive Hebbian learning forms functional recurrent networks.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
47 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
Synapses are plastic and can be modified by changes in spike timing. Whereas most studies of long-term synaptic plasticity focus on excitation, inhibitory plasticity may be critical for controlling information processing, memory storage, and overall excitability in neural circuits. Here we examine spike-timing-dependent plasticity (STDP) of inhibitory synapses onto layer 5 neurons in slices of mouse auditory cortex, together with concomitant STDP of excitatory synapses. Pairing pre- and postsynaptic spikes potentiated inhibitory inputs irrespective of precise temporal order within ∼10 ms. This was in contrast to excitatory inputs, which displayed an asymmetrical STDP time window. These combined synaptic modifications both required NMDA receptor activation and adjusted the excitatory-inhibitory ratio of events paired with postsynaptic spiking. Finally, subthreshold events became suprathreshold, and the time window between excitation and inhibition became more precise. These findings demonstrate that cortical inhibitory plasticity requires interactions with co-activated excitatory synapses to properly regulate excitatory-inhibitory balance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.