ArticleNeuron2015
Circuit mechanisms underlying motor memory formation in the cerebellum.
Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
87 citing papers in PubMed, 157 citations in OpenAlex.
- Investigating the feasibility of cerebellar transcranial direct current stimulation to facilitate post-stroke overground gait performance in chronic stroke: a partial least-squares regression approach.Journal of neuroengineering and rehabilitation · 2021Trial
- Cerebellar activity is triggered by reach endpoint during learning of a complex locomotor task.Nature communications · 2026Article
- Contextual effects during sensorimotor adaptation are an emergent property of population coding in a cerebellar-inspired model.Science advances · 2025Article
- A theory of cerebellar learning as spike-based reinforcement learning in continuous time and space.PNAS nexus · 2025Article
- Article
- Purkinje cells of the cerebellum control deceleration of tongue movements.PLoS biology · 2025Article
- The cerebellum engages multiple pre-motor pathways through a divergent-convergent architecture to shape whisker dynamics.Frontiers in neural circuits · 2025Article
- Exploring brain plasticity in developmental dyslexia through implicit sequence learning.NPJ science of learning · 2024Article
- Climbing fibers provide essential instructive signals for associative learning.Nature neuroscience · 2024Article
- A cerebellar population coding model for sensorimotor learning.bioRxiv : the preprint server for biology · 2024Article
- Article
- Environmental enrichment reduces restricted repetitive behavior by altering gray matter microstructure.PloS one · 2024Article
- Correlated signatures of social behavior in cerebellum and anterior cingulate cortex.bioRxiv : the preprint server for biology · 2023Article
- Synaptic variance and action potential firing of cerebellar output neurons during motor learning in larval zebrafish.Current biology : CB · 2023Article
- Development, circuitry, and function of the zebrafish cerebellum.Cellular and molecular life sciences : CMLS · 2023Review
- Purkinje cell microzones mediate distinct kinematics of a single movement.Nature communications · 2023Article
- Cerebellar associative learning underlies skilled reach adaptation.Nature neuroscience · 2023Article
- Expression of a Form of Cerebellar Motor Memory Requires Learned Alterations to the Activity of Inhibitory Molecular Layer Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- KCa1.1 channels contribute to optogenetically driven post-stimulation silencing in cerebellar molecular layer interneurons.The Journal of general physiology · 2023Article
- Cerebellar malfunction and postoperative sleep disturbances after general anesthesia: a narrative review.Sleep & breathing = Schlaf & Atmung · 2022Review
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The cerebellum stores associative motor memories essential for properly timed movement; however, the mechanisms by which these memories form and are acted upon remain unclear. To determine how cerebellar activity relates to movement and motor learning, we used optogenetics to manipulate spontaneously firing Purkinje neurons (PNs) in mouse simplex lobe. Using high-speed videography and motion tracking, we found that altering PN activity produced rapid forelimb movement. PN inhibition drove movements time-locked to stimulus onset, whereas PN excitation drove delayed movements time-locked to stimulus offset. Pairing either PN inhibition or excitation with sensory stimuli triggered the formation of robust, associative motor memories; however, PN excitation led to learned movements whose timing more closely matched training intervals. These findings implicate inhibition of PNs as a teaching signal, consistent with a model whereby learning leads first to reductions in PN firing that subsequently instruct circuit changes in the cerebellar nucleus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.