Evidence map›Paper›PMID 25843394›Full record

ArticleEpidemics2015

Modelling challenges in context: lessons from malaria, HIV, and tuberculosis.

Lauren M Childs, Nadia N Abuelezam, Christopher Dye, Sunetra Gupta, Megan B Murray, Brian G Williams, Caroline O Buckee

Open access · goldAbstract read
In one paragraph

Article in Epidemics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Lauren M ChildsCenter for Communicable Disease Dynamics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States.
Nadia N AbuelezamDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States.
Christopher DyeOffice of the Director General, World Health Organization, Avenue Appia, 1211 Geneva 27, Switzerland.
Sunetra GuptaDepartment of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom.
Megan B MurrayDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States; Division of Global Health Equity, Brigham & Women's Hospital, Boston, MA 02115, United States.
Brian G WilliamsSouth African Centre for Epidemiological Modelling and Analysis, Stellenbosch, South Africa; Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg, South Africa.
Caroline O BuckeeCenter for Communicable Disease Dynamics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. Electronic address: cbuckee@hsph.harvard.edu.
Center for Disease Dynamics, Economics & Policy · USHarvard University · USUniversity of Oxford · GBUniversity of the Witwatersrand · ZAWorld Health Organization · CH

Funding

Understanding and controlling antibiotic resistanceU54GM088558 · NIGMS · HARVARD SCHOOL OF PUBLIC HEALTH · PI HANAGE, WILLIAM · 2009 to 2018
$26.4M
PROGRAM FOR AIDS CLINICAL RESEARCH TRAINING (PACRT)T32AI007433 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MARK J SIEDNER · 1992 to 2026
$11.4M
Modeling the Impact of HIV Prevention InterventionsR01MH087328 · NIMH · HARVARD SCHOOL OF PUBLIC HEALTH · PI SEAGE, GEORGE R · 2010 to 2013
$2.7M
NIAID NIH HHS T32 AI007433NIGMS NIH HHS U54 GM088558NIGMS NIH HHS U54GM088558NIMH NIH HHS R01 MH087328NIMH NIH HHS R01MH087328-03PHS HHS AWARDNIAID AI 007433World Health Organization 001
6 · The paper itself

Abstract

Malaria, HIV, and tuberculosis (TB) collectively account for several million deaths each year, with all three ranking among the top ten killers in low-income countries. Despite being caused by very different organisms, malaria, HIV, and TB present a suite of challenges for mathematical modellers that are particularly pronounced in these infections, but represent general problems in infectious disease modelling, and highlight many of the challenges described throughout this issue. Here, we describe some of the unifying challenges that arise in modelling malaria, HIV, and TB, including variation in dynamics within the host, diversity in the pathogen, and heterogeneity in human contact networks and behaviour. Through the lens of these three pathogens, we provide specific examples of the other challenges in this issue and discuss their implications for informing public health efforts.

Indexed as

Genetic VariationHIVHIV InfectionsHost-Pathogen InteractionsHumansMalariaModels, StatisticalMycobacterium tuberculosisTuberculosis, PulmonaryHIVMalariaModellingTuberculosis

Identifiers

PMID25843394
PMCPMC4451070
OpenAlexW2101985175

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.