Evidence map›Paper›PMID 25843391›Full record

ArticleEpidemics2015

Eight challenges in phylodynamic inference.

Simon D W Frost, Oliver G Pybus, Julia R Gog, Cecile Viboud, Sebastian Bonhoeffer, Trevor Bedford

Abstract read
In one paragraph

Article in Epidemics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed.

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  13. Identifying changes in viral fitness using population genetic structure.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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  18. Population genomics of diarrheagenic Escherichia coli uncovers high connectivity between urban and rural communities in Ecuador.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2023
    Article
  19. Review
  20. Review

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Simon D W FrostDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK; Institute of Public Health, University of Cambridge, Cambridge, UK. Electronic address: sdf22@cam.ac.uk.
Oliver G PybusDepartment of Zoology, University of Oxford, Oxford, UK.
Julia R GogDepartment of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK.
Cecile ViboudFogarty International Center, National Institutes of Health, Bethesda, USA.
Sebastian BonhoefferInstitute of. Integrative Biology, ETH Zurich, Zurich, Switzerland.
Trevor BedfordVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, USA.

Funding

Medical Research Council MR/J013862/1
6 · The paper itself

Abstract

The field of phylodynamics, which attempts to enhance our understanding of infectious disease dynamics using pathogen phylogenies, has made great strides in the past decade. Basic epidemiological and evolutionary models are now well characterized with inferential frameworks in place. However, significant challenges remain in extending phylodynamic inference to more complex systems. These challenges include accounting for evolutionary complexities such as changing mutation rates, selection, reassortment, and recombination, as well as epidemiological complexities such as stochastic population dynamics, host population structure, and different patterns at the within-host and between-host scales. An additional challenge exists in making efficient inferences from an ever increasing corpus of sequence data.

Indexed as

PhylogenyBiological EvolutionCommunicable DiseasesGenetic VariationHost-Pathogen InteractionsHumansModels, StatisticalPopulation DynamicsRecombination, GeneticSelection, GeneticStochastic ProcessesCoalescent modelsPhylodynamicsRecombinationSelection

Identifiers

PMID25843391
PMCPMC4383806

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.