Evidence map›Paper›PMID 25843389›Full record

ArticleEpidemics2015

Seven challenges for model-driven data collection in experimental and observational studies.

J Lessler, W J Edmunds, M E Halloran, T D Hollingsworth, A L Lloyd

Open access · goldAbstract read
In one paragraph

Article in Epidemics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
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  6. Article
  7. Article
  8. Article
  9. Article
  10. Modeling the Transmission ofFrontiers in veterinary science · 2019
    Article
  11. Article
  12. Key data for outbreak evaluation: building on the Ebola experience.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017
    Review
  13. Article
  14. Comparing nonpharmaceutical interventions for containing emerging epidemics.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

J LesslerDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21224, USA. Electronic address: justin@jhu.edu.
W J EdmundsLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
M E HalloranDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA 98195 USA; Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
T D HollingsworthMathematics Institute, University of Warwick, Coventry CV4 7AL, UK; School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK; Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
A L LloydDepartment of Mathematics and Biomathematics Graduate Program, North Carolina State University, Raleigh, NC 27695, USA; Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA.
Johns Hopkins University · USLiverpool School of Tropical Medicine · GBNational Institutes of Health · USUniversity of London · GBUniversity of Washington · US

Funding

Understanding Transmission with Integrated Genetic and Epidemiologic InferenceU54GM111274 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI VESPIGNANI, ALESSANDRO · 2014 to 2018
$12.5M
Containing Bioterrorist and Emerging Infectious DiseasesU01GM070749 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HALLORAN, M ELIZABETH, LONGINI, IRA M · 2004 to 2013
$8.3M
Surveillance Core (B)P01AI098670 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KITRON, URIEL DAN · 2014 to 2018
$7.9M
Methods for Evaluating Vaccine EfficacyR37AI032042 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HALLORAN, M ELIZABETH · 2010 to 2019
$5.1M
Improving Robustness of a Tactical Model of Aedes/Dengue DynamicsR01AI091980 · NIAID · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI GOULD, FRED · 2011 to 2014
$1.3M
Estimation of Intervention Effects in Influenza OutbreaksK22AI092150 · NIAID · JOHNS HOPKINS UNIVERSITY · PI LESSLER, JUSTIN · 2011 to 2012
$270k
NIAID NIH HHS K22 AI092150NIAID NIH HHS K22-AI092150-01NIAID NIH HHS P01 AI098670NIAID NIH HHS P01-AI098670NIAID NIH HHS R01 AI091980NIAID NIH HHS R01-AI091980NIAID NIH HHS R37 AI032042NIAID NIH HHS R37-AI032042NIGMS NIH HHS U01 GM070749NIGMS NIH HHS U54 GM111274NIGMS NIH HHS U54-GM111274Wellcome TrustWellcome Trust 097830/Z/11/A-C
6 · The paper itself

Abstract

Infectious disease models are both concise statements of hypotheses and powerful techniques for creating tools from hypotheses and theories. As such, they have tremendous potential for guiding data collection in experimental and observational studies, leading to more efficient testing of hypotheses and more robust study designs. In numerous instances, infectious disease models have played a key role in informing data collection, including the Garki project studying malaria, the response to the 2009 pandemic of H1N1 influenza in the United Kingdom and studies of T-cell immunodynamics in mammals. However, such synergies remain the exception rather than the rule; and a close marriage of dynamic modeling and empirical data collection is far from the norm in infectious disease research. Overcoming the challenges to using models to inform data collection has the potential to accelerate innovation and to improve practice in how we deal with infectious disease threats.

Indexed as

Communicable DiseasesData CollectionEpidemiologic Research DesignHumansModels, StatisticalObservational Studies as TopicData collectionExperimental studiesModelingObservational studies

Identifiers

PMID25843389
PMCPMC4387311
OpenAlexW2082463731

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.