Evidence map›Paper›PMID 25843053›Full record

ArticleClinical oral investigations2016

Zoledronate induces bisphosphonate-related osteonecrosis of the jaw in osteopenic sheep.

Pit J Voss, Martin J Stoddart, Anke Bernstein, Rainer Schmelzeisen, Katja Nelson, Vincent Stadelmann, Thomas Ziebart, Philipp J Poxleitner

Abstract read
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In one paragraph

Article in Clinical oral investigations, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Pit J VossDepartment of Oral and Maxillofacial Surgery, University Medical Center Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany. pit.voss@uniklinik-freiburg.de.
Martin J StoddartAO Research Institute Davos, Clavadelerstr. 8, 7270, Davos, Switzerland. martin.stoddart@aofoundation.org.
Anke BernsteinDepartment of Orthopedics and Traumatology, University Medical Center Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany. anke.bernstein@uniklinik-freiburg.de.
Rainer SchmelzeisenDepartment of Oral and Maxillofacial Surgery, University Medical Center Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany. rainer.schmelzeisen@uniklinik-freiburg.de.
Katja NelsonDepartment of Oral and Maxillofacial Surgery, University Medical Center Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany. katja.nelson@uniklinik-freiburg.de.
Vincent StadelmannAO Research Institute Davos, Clavadelerstr. 8, 7270, Davos, Switzerland. vincent.stadelmann@aofoundation.org.
Thomas ZiebartDepartment of Oral and Maxillofacial Surgery, University Hospital Mainz, Augustusplatz 2, 55131, Mainz, Germany. ziebart@mkg.klinik.uni-mainz.de.
Philipp J PoxleitnerDepartment of Oral and Maxillofacial Surgery, University Medical Center Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany. philipp.poxleitner@uniklinik-freiburg.de.
University Medical Center Freiburg · DEAO Foundation · CHJohannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesBisphosphonate-related osteonecrosis of the jaw (BP-ONJ) occurs in 1 % of patients with medication-induced osteoporosis treated with bisphosphonates. Sheep are an established large animal model for investigating osteoporotic skeletal changes. Zoledronate significantly reduces tissue mineral variability in ovariectomized sheep. The aim of this study was to analyze bone healing after tooth extraction in sheep with induced osteopenia and zoledronate administration. MATERIALS AND

methodsEight adult ewes were randomly divided into two groups of four animals. All sheep underwent ovariectomy and a low-calcium diet. Dexamethasone was administered weekly for 16 weeks. Zoledronate was then given every third week for a further 16 weeks in four sheep; these infusions were repeated after extraction of two lower premolars. Four sheep without zoledronate administrations served as controls.

resultsDue to general health conditions, two sheep of the zoledronate group had to be excluded before surgery. The remaining two sheep of this group developed BP-ONJ lesions at the extraction site and various other sites in both jaws. Control group animals showed uneventful wound healing. Histology of the alveolar processes as well as lumbar spine revealed larger portions of old bone and smaller portions of new bone in the zoledronate group.

conclusionsThis animal study showed uneventful wound healing after tooth extraction in osteopenic sheep whereas zoledronate treatment leads to development of BP-ONJ-like lesions. CLINICAL RELEVANCE: As bisphosphonate administration is a standard treatment for glucocorticoid-induced osteoporosis, this model can be used for further research in pathogenesis and management of bisphosphonate-related adverse events.

Indexed as

AnimalsBisphosphonate-Associated Osteonecrosis of the JawBone Diseases, MetabolicDexamethasoneDiphosphonatesDisease Models, AnimalFemaleImidazolesOvariectomyRandom AllocationSheep, DomesticTooth ExtractionWound HealingZoledronic AcidDexamethasoneDiphosphonatesImidazolesZoledronic AcidBisphosphonatesLarge animal studyOral and maxillofacial surgeryOral pathologyOsteoporosisOvariectomyWound healing

Identifiers

PMID25843053
OpenAlexW2067386207

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.