ArticleComputers in biology and medicine2015
Analysis of speed, curvature, planarity and frequency characteristics of heart vector movement to evaluate the electrophysiological substrate associated with ventricular tachycardia.
Article in Computers in biology and medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Anatomical-electrical coupling of cardiac axes: Definitions and population variability for advancing personalised ECG interpretation.PLoS computational biology · 2025Article
- Article
- Vectorgastrogram: dynamic trajectory and recurrence quantification analysis to assess slow wave vector movement in healthy subjects.Physical and engineering sciences in medicine · 2024Article
- Pulmonary Hypertension Detection Non-Invasively at Point-of-Care Using a Machine-Learned Algorithm.Diagnostics (Basel, Switzerland) · 2024Article
- Plasticizer Interaction With the Heart: Chemicals Used in Plastic Medical Devices Can Interfere With Cardiac Electrophysiology.Circulation. Arrhythmia and electrophysiology · 2019Article
- Wearable sensors for monitoring the internal and external workload of the athlete.NPJ digital medicine · 2019Review
- Frequency content and characteristics of ventricular conduction.Journal of electrocardiologyReview
- Correlation between the high-frequency content of the QRS on murine surface electrocardiogram and the sympathetic nerves density in left ventricle after myocardial infarction: Experimental study.Journal of electrocardiologyArticle
- Optimal configuration of adhesive ECG patches suitable for long-term monitoring of a vectorcardiogram.Journal of electrocardiologyArticle
- Quantitative Assessment of Vectorcardiographic Loop Morphology.Journal of electrocardiologyArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWe developed a novel method of assessing ventricular conduction using the surface ECG.
methodsOrthogonal ECGs of 81 healthy controls (age 39.0±14.2 y; 51.8% males; 94% white), were compared with iDower-transformed 12-lead ECGs (both 1000Hz), recorded in 8 patients with infarct-cardiomyopathy and sustained monomorphic ventricular tachycardia (VT) (age 68.0±7.8y, 37.5% male, mean LVEF 29±12%). Normalized speed at 10 QRS segments was calculated as the distance traveled by the heart vector along the QRS loop in three-dimensional space, divided by 1/10th of the QRS duration. Curvature was calculated as the magnitude of the derivative of the QRS loop tangent vector divided by speed. Planarity was calculated as the mean of the dihedral angles between 2 consecutive planes for all planes generated for the median beat. Orbital frequency (a scalar measure of rotation rate of the QRS vector) was calculated as a product of speed and curvature.
resultsMixed regression analysis showed that speed was slower [6.6 (95%CI 4.4-8.9) vs. 24.6 (95%CI 11.5-37.7)µV/ms; P<0.0001]; orbital frequency was smaller [1.4 (95%CI 1.2-1.6) vs. 6.8 (95%CI 5.4-8.1)ms(-1); P<0.0001], and planarity was larger by 3.6° (95%CI 1.4°-5.8; P=0.002) in VT cases than in healthy controls. ROC AUC for orbital frequency was 0.940 (95%CI 0.935-0.944) across all frequencies and QRS segments. ROC AUC for planarity at 70-249Hz was 0.995 (95%CI 0.985-1.00). ROC AUC for speed at 70-79Hz was 0.979 (95%CI 0.969-0.989).
conclusionThis novel method reveals characteristic features of an abnormal electrophysiological substrate associated with VT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.