ArticleWorld journal of microbiology & biotechnology2015
Comparative investigation of the various determinants that influence the codon and amino acid usage patterns in the genus Bifidobacterium.
Article in World journal of microbiology & biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- UsingGut microbes reports · 2026Article
- Distinct codon usage signatures reflecting evolutionary and pathogenic adaptation in the Acinetobacter baumannii complex.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Article
- Comparative genome wise analysis of codon usage of Staphylococcus Genus.Current genetics · 2024Article
- Detection of the peptidyl epitope for vaccine development against MPV.Journal of King Saud University. Science · 2023Article
- Pan-genome evolution and its association with divergence of metabolic functions in Bifidobacterium genus.World journal of microbiology & biotechnology · 2022Article
- Adaptability and Evolution of Gobiidae: A Genetic Exploration.Animals : an open access journal from MDPI · 2022Article
- Complete mitogenome of endemic plum-headed parakeet Psittacula cyanocephala - characterization and phylogenetic analysis.PloS one · 2021Article
- Codon usage signatures in Sabia and Chapare for host adaptation.Bioinformation · 2021Article
- Turdoides affinis mitogenome reveals the translational efficiency and importance of NADH dehydrogenase complex-I in the Leiothrichidae family.Scientific reports · 2020Article
- Comprehensive profiling of codon usage signatures and codon context variations in the genus Ustilago.World journal of microbiology & biotechnology · 2019Article
- Comparative evolutionary genomics of Corynebacterium with special reference to codon and amino acid usage diversities.Genetica · 2018Article
- HIV Progression Depends on Codon and Amino Acid Usage Profile of Envelope Protein and Associated Host-Genetic Influence.Frontiers in microbiology · 2017Article
- Host Plant Compatibility Shapes the Proteogenome ofFrontiers in microbiology · 2017Article
- Multiple Evolutionary Selections Involved in Synonymous Codon Usages in the Streptococcus agalactiae Genome.International journal of molecular sciences · 2016Article
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4 authors.
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Abstract
Various strains of the genus Bifidobacterium are crucial members of the human, animal and insect gut, associated with beneficial probiotic activities. An extensive analysis on codon and amino acid usage of the GC rich genus Bifidobacterium has been executed in the present study. Multivariate statistical analysis revealed a coupled effect of GC compositional constraint and natural selection for translational efficiency to be operative in producing the observed codon usage variations. Gene expression level was inferred to be the most crucial factor governing the codon usage patterns. Amino acid usage was found to be influenced significantly by hydrophobic and aromatic character of the encoded proteins. Gene expressivity and protein energetic cost also had considerable impact on the differential mode of amino acid usage. The genus was found to strictly obey the cost-minimization hypothesis as was reflected from the amino acid usage patterns of the potential highly expressed gene products. Evolutionary analysis revealed that the highly expressed genes were candidates to extreme evolutionary selection pressure and indicated a high degree of conservation at the proteomic level. Interestingly, the complimentary strands of replication appeared to evolve under similar evolutionary constraints which might be addressed as a consequence of absence of replicational selection and lack of strand-specific asymmetry among the members of the genus. Thus, the present endeavor confers considerable know-how pertaining to the codon and amino acid usage intricacies in Bifidobacterium and might prove handy for further scientific investigations associated with the concerned domain.
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