Evidence map›Paper›PMID 25842202›Full record

ArticleBiological psychiatry2016

Structural Plasticity of the Hippocampus and Amygdala Induced by Electroconvulsive Therapy in Major Depression.

Shantanu H Joshi, Randall T Espinoza, Tara Pirnia, Jie Shi, Yalin Wang, Brandon Ayers, Amber Leaver, Roger P Woods, Katherine L Narr

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03040388 (Predicting Effects and Risk of Relapse Into Depression - The Danish ECT/MRI Project), which is not on this map. Cited by 144 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03040388 completednot on this mapstarted 2017, after this paper: background citation

Predicting Effects and Risk of Relapse Into Depression - The Danish ECT/MRI Project

TypeobservationalSponsorUniversity of CopenhagenRan2017 to 2020Enrolled26ConditionsDepressive Disorder, Depression, Depressive Disorder, Major
3 · Its place in the literature

Who cites it

144 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review

84 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Shantanu H JoshiAhmanson-Lovelace Brain Mapping Center, Department of Neurology, University of California at Los Angeles, Los Angeles, California.
Randall T EspinozaDepartment of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, California.
Tara PirniaAhmanson-Lovelace Brain Mapping Center, Department of Neurology, University of California at Los Angeles, Los Angeles, California.
Jie ShiSchool of Computing, Informatics, and Decision Systems Engineering, Arizona State University, AZ.
Yalin WangSchool of Computing, Informatics, and Decision Systems Engineering, Arizona State University, AZ.
Brandon AyersAhmanson-Lovelace Brain Mapping Center, Department of Neurology, University of California at Los Angeles, Los Angeles, California.
Amber LeaverAhmanson-Lovelace Brain Mapping Center, Department of Neurology, University of California at Los Angeles, Los Angeles, California.
Roger P WoodsAhmanson-Lovelace Brain Mapping Center, Department of Neurology, University of California at Los Angeles, Los Angeles, California; Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, California.
Katherine L NarrAhmanson-Lovelace Brain Mapping Center, Department of Neurology, University of California at Los Angeles, Los Angeles, California; Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, California. Electronic address: narr@ucla.edu.

Funding

Imaging biomarkers of ECT response in major depressive disorderR01MH092301 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ESPINOZA, RANDALL, NARR, KATHERINE L · 2011 to 2015
$4.0M
Biomarkers of fast acting therapies in major depressionK24MH102743 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NARR, KATHERINE L · 2014 to 2018
$889k
MRI Biomarker Discovery for Preclinical Alzheimers Disease with Geometry MethodsR21AG043760 · NIA · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI WANG, YALIN · 2013 to 2014
$409k
NIA NIH HHS R21 AG043760NIMH NIH HHS K24 MH102743NIMH NIH HHS K24MH102743NIMH NIH HHS R01 MH092301NIMH NIH HHS R01MH092301
6 · The paper itself

Abstract

backgroundElectroconvulsive therapy (ECT) elicits a rapid and robust clinical response in patients with refractory depression. Neuroimaging measurements of structural plasticity relating to and predictive of ECT response may point to the mechanisms underlying rapid antidepressant effects and establish biomarkers to inform other treatments. Here, we determine the effects of diagnosis and of ECT on global and local variations of hippocampal and amygdala structures in major depression and predictors of ECT-related clinical response.

methodsLongitudinal changes in hippocampal and amygdala structures were examined in patients with major depression (N = 43, scanned three times: prior to ECT, after the second ECT session, and within 1 week of completing the ECT treatment series), referred for ECT as part of their standard clinical care. Cross-sectional comparisons with demographically similar controls (N = 32, scanned twice) established effects of diagnosis.

resultsPatients showed smaller hippocampal volumes than controls at baseline (p < .04). Both the hippocampal and the amygdala volumes increased with ECT (p < .001) and in relation to symptom improvement (p < .01). Hippocampal volume at baseline predicted subsequent clinical response (p < .05). Shape analysis revealed pronounced morphometric changes in the anterior hippocampus and basolateral and centromedial amygdala. All structural measurements remained stable across time in controls.

conclusionsECT-induced neuroplasticity in the hippocampus and amygdala relates to improved clinical response and is pronounced in regions with prominent connections to ventromedial prefrontal cortex and other limbic structures. Smaller hippocampal volumes at baseline predict a more robust clinical response. Neurotrophic processes including neurogenesis shown in preclinical studies may underlie these structural changes.

Indexed as

Neuronal PlasticityAdultAmygdalaCross-Sectional StudiesDepressive Disorder, Treatment-ResistantElectroconvulsive TherapyFemaleHippocampusHumansMajor Depressive DisorderMaleMiddle AgedPsychiatric Status Rating ScalesTreatment OutcomeAntidepressantBrain stimulationECTLimbicNeuroimagingNeuroplasticity

Identifiers

PMID25842202
PMCPMC4561035

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.