ArticleDrug and alcohol dependence2015
Altered white matter in cocaine-dependent subjects with traumatic brain injury: A diffusion tensor imaging study.
Article in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- The second decade of DTI in TBI part 1: a systematic review of mild TBI.Frontiers in neurologyPooled it
- Trial
- PPAR-gamma agonist pioglitazone modifies craving intensity and brain white matter integrity in patients with primary cocaine use disorder: a double-blind randomized controlled pilot trial.Addiction (Abingdon, England) · 2017Trial
- Imaging neuroinflammation in individuals with substance use disorders.The Journal of clinical investigation · 2024Review
- Chronic Cocaine Use and White Matter Coherence: A Diffusion Tensor Imaging Study.Journal of studies on alcohol and drugs · 2023Article
- Cocaine self-administration is increased after frontal traumatic brain injury and associated with neuroinflammation.The European journal of neuroscience · 2019Article
- Executive (dys)function after traumatic brain injury: special considerations for behavioral pharmacology.Behavioural pharmacology · 2018Review
- Cocaine dependence does not contribute substantially to white matter abnormalities in HIV infection.Journal of neurovirology · 2017Article
- Natural Compounds as a Therapeutic Intervention following Traumatic Brain Injury: The Role of Phytochemicals.Journal of neurotrauma · 2017Review
- A preliminary longitudinal study of white matter alteration in cocaine use disorder subjects.Drug and alcohol dependence · 2017Article
- Shared microstructural features of behavioral and substance addictions revealed in areas of crossing fibers.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
- White matter deficits assessed by diffusion tensor imaging and cognitive dysfunction in psychostimulant users with comorbid human immunodeficiency virus infection.BMC research notes · 2015Article
- Effect of cocaine dependence on brain connections: clinical implications.Expert review of neurotherapeutics · 2015Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDiffusion tensor imaging (DTI) is a useful technique for non-invasively investigating the microstructural organization of white matter (WM), and the most consistent DTI finding regarding cocaine-related WM alterations is in the corpus callosum (CC). WM injury has also been observed in subjects with traumatic brain injury (TBI), including in the CC.
methodsWe used DTI to test if the WM microstructure is relatively more impaired in cocaine-dependent subjects who had suffered a mild TBI (mTBI). Fractional anisotropy (FA), which reflects the degree of alignment of cellular structures within fiber tracts and their structural integrity, was compared across cocaine-dependent subjects with mTBI (COCTBI group, n = 9), matched cocaine-dependent subjects without TBI (COC group, n = 12), and matched healthy controls (CTL group, n = 12).
resultsThe COCTBI group had significantly lower FA in the genu, body, and splenium of CC, than the CTL group whenever the education was controlled or not. The COC group had significantly lower FA in the left and right anterior corona radiata than the CTL group only when the education was controlled. There was no significant difference in FA between the COC and COCTBI groups.
conclusionCocaine dependence (or mTBI) related WM impairments in the CC were not detectable in this small subject sample. The significant finding in the CC suggests that the concurrence of cocaine dependence and mTBI might result in more severe damage to the CC, which could even be detected in small sample size.
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