ArticleNeuroscience letters2015
Histidine decarboxylase knockout mice, a genetic model of Tourette syndrome, show repetitive grooming after induced fear.
Article in Neuroscience letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 55 citations in OpenAlex.
- The Sapap3Translational psychiatry · 2023Article
- Role of histidine decarboxylase gene in the pathogenesis of Tourette syndrome.Brain and behavior · 2022Review
- White matter abnormalities in theFrontiers in molecular neuroscience · 2022Article
- Genetic background determines behavioral responses during fear conditioning.Neurobiology of learning and memory · 2021Article
- Establishment and evaluation of a compound fear behavior model of Tourette's syndrome in rats.Annals of translational medicine · 2021Article
- Immunological Dysfunction in Tourette Syndrome and Related Disorders.International journal of molecular sciences · 2021Review
- Mutations in ASH1L confer susceptibility to Tourette syndrome.Molecular psychiatry · 2020Article
- The histidine decarboxylase model of tic pathophysiology: a new focus on the histamine HBritish journal of pharmacology · 2020Review
- Association of Rare Genetic Variants in Opioid Receptors with Tourette Syndrome.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Article
- Striatal Signaling Regulated by the H3R Histamine Receptor in a Mouse Model of tic Pathophysiology.Neuroscience · 2018Article
- Tourette syndrome: a disorder of the social decision-making network.Brain : a journal of neurology · 2018Review
- Molecular Regulation of Histamine Synthesis.Frontiers in immunology · 2018Review
- Modeling tics in rodents: Conceptual challenges and paths forward.Journal of neuroscience methods · 2017Review
- Histamine modulation of the basal ganglia circuitry in the development of pathological grooming.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- What makes you tic? Translational approaches to study the role of stress and contextual triggers in Tourette syndrome.Neuroscience and biobehavioral reviews · 2017Review
- Rodent models of obsessive compulsive disorder: Evaluating validity to interpret emerging neurobiology.Neuroscience · 2017Review
- Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders.Translational psychiatry · 2017Article
- Histidine Decarboxylase Knockout Mice as a Model of the Pathophysiology of Tourette Syndrome and Related Conditions.Handbook of experimental pharmacology · 2017Review
- The Histamine H3 Receptor Differentially Modulates Mitogen-activated Protein Kinase (MAPK) and Akt Signaling in Striatonigral and Striatopallidal Neurons.The Journal of biological chemistry · 2016Article
- 'Stressing' rodent self-grooming for neuroscience research.Nature reviews. Neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Tics, such as are seen in Tourette syndrome (TS), are common and can cause profound morbidity, but they are poorly understood. Tics are potentiated by psychostimulants, stress, and sleep deprivation. Mutations in the gene histidine decarboxylase (Hdc) have been implicated as a rare genetic cause of TS, and Hdc knockout mice have been validated as a genetic model that recapitulates phenomenological and pathophysiological aspects of the disorder. Tic-like stereotypies in this model have not been observed at baseline but emerge after acute challenge with the psychostimulant d-amphetamine. We tested the ability of an acute stressor to stimulate stereotypies in this model, using tone fear conditioning. Hdc knockout mice acquired conditioned fear normally, as manifested by freezing during the presentation of a tone 48h after it had been paired with a shock. During the 30min following tone presentation, knockout mice showed increased grooming. Heterozygotes exhibited normal freezing and intermediate grooming. These data validate a new paradigm for the examination of tic-like stereotypies in animals without pharmacological challenge and enhance the face validity of the Hdc knockout mouse as a pathophysiologically grounded model of tic disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.