Evidence map›Paper›PMID 25841575›Full record

Observational studyGastrointestinal endoscopy2015

Sex and race and/or ethnicity differences in patients undergoing radiofrequency ablation for Barrett's esophagus: results from the U.S. RFA Registry.

Sarina Pasricha, Nan Li, William J Bulsiewicz, Richard I Rothstein, Anthony Infantolino, Atilla Ertan, Daniel S Camara, Evan S Dellon, George Triadafilopoulos, Charles J Lightdale and 5 more

Open access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Gastrointestinal endoscopy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Endoscopic management of esophageal cancer.World journal of gastrointestinal oncology · 2019
    Review
  2. Precision care for Barrett's esophagus.Translational gastroenterology and hepatology · 2018
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Sarina PasrichaCenter for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Nan LiCenter for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
William J BulsiewiczCenter for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Richard I RothsteinDartmouth University School of Medicine, Hanover, New Hampshire, USA.
Anthony InfantolinoThomas Jefferson University School of Medicine, Philadelphia, Pennsylvania, USA.
Atilla ErtanUniversity of Texas School of Medicine, Houston, Texas, USA.
Daniel S CamaraDigestive Health Physicians, Cheektowaga, New York, USA.
Evan S DellonCenter for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
George TriadafilopoulosStanford University School of Medicine, Palo Alto, California, USA.
Charles J LightdaleColumbia University School of Medicine, New York, New York, USA.
Ryan D MadanickCenter for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
William D LydayAtlanta Gastroenterology Associates, Atlanta, Georgia, USA.
Raman V MuthusamyUCLA School of Medicine, Los Angeles, California, USA.
Bergein F OverholtGastrointestinal Associates, Knoxville, Tennessee, USA.
Nicholas J ShaheenCenter for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
University of North Carolina at Chapel Hill · USAtlanta Gastroenterology Associates · USColumbia University · USDartmouth College · USDigestive Care (United States) · USPalo Alto University · USThomas Jefferson University · USUniversity of California, Los Angeles · US

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5M
DIGESTIVE DISEASES EPIDEMIOLOGY TRAINING PROGRAMT32DK007634 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1990 to 2026
$7.4M
Non-Endoscopic Surveillance for Barrett's Esophagus Following Ablative TherapyK24DK100548 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHAHEEN, NICHOLAS J · 2013 to 2017
$896k
NIDDK NIH HHS K24 DK100548NIDDK NIH HHS K24DK100548NIDDK NIH HHS P30 DK034987NIDDK NIH HHS T32 DK007634NIDDK NIH HHS T32 DK07634
6 · The paper itself

Abstract

backgroundLittle is known about differences in Barrett's esophagus (BE) characteristics by sex and race and/or ethnicity or these differences in response to radiofrequency ablation (RFA).

objectiveWe compared disease-specific characteristics, treatment efficacy, and safety outcomes by sex and race and/or ethnicity in patients treated with RFA for BE.

designThe U.S. RFA patient registry is a multicenter collaboration reporting processes and outcomes of care for patients treated with RFA for BE. PATIENTS: Patients enrolled with BE.

interventionsRFA. MAIN OUTCOME MEASUREMENTS: We assessed safety (stricture, bleeding, perforation, hospitalization), efficacy (complete eradication of intestinal metaplasia [CEIM]), complete eradication of dysplasia, and number of treatments to CEIM by sex and race and/or ethnicity.

resultsAmong 5521 patients (4052 men; 5126 white, 137 Hispanic, 82 African American, 40 Asian, 136 heritage not identified), women were younger (60.0 vs 62.1 years) and had shorter BE segments (3.2 vs 4.4 cm) and less dysplasia (37% vs 57%) than did men. Women were almost twice as likely to stricture (odds ratio 1.7; 95% confidence interval, 1.2-2.3). Although white patients were predominantly male, about half of African Americans and Asians with BE were female. African Americans and Asians had less dysplasia than white patients. Asians and African Americans had more strictures than did white patients. There were no sex or race differences in efficacy. LIMITATIONS: Observational study with non-mandated paradigms, no central laboratory for reinterpretation of pathology.

conclusionIn the U.S. RFA patient registry, women had shorter BE segments and less-aggressive histology. The usual tendency toward BE in men was absent in African Americans and Asians. Posttreatment stricture was more common among women and Asians. RFA efficacy did not differ by sex or race.

Indexed as

Catheter AblationAgedAsianBarrett EsophagusBlack or African AmericanEsophageal PerforationEsophageal StenosisFemaleGastrointestinal HemorrhageHispanic or LatinoHospitalizationHumansIndians, North AmericanMaleMiddle AgedPopulation Groups

Identifiers

PMID25841575
PMCPMC4506693
OpenAlexW2072733819

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.