ArticleJournal of biomechanics2015
Hemodynamic study of TCPC using in vivo and in vitro 4D Flow MRI and numerical simulation.
Article in Journal of biomechanics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Non-Invasive Evaluation of Pulmonary Artery Stenosis in Congenital Heart Disease Patients Using Phase Contrast MRI.Cardiovascular engineering and technology · 2026Article
- The utility of 4D flow MRI and computational fluid dynamics in developing the fontan model enhances presurgical planning and ensures better outcomes: the first case report in Thailand.Journal of cardiothoracic surgery · 2026Article
- Four-Dimensional Flow in Fontan Patients: Advanced Haemodynamic Assessment.Journal of clinical medicine · 2025Review
- Technological evolution ofFrontiers in physiology · 2025Review
- Hemodynamics and Wall Mechanics of Vascular Graft Failure.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- Optimization of 4D Flow MRI Spatial and Temporal Resolution for Examining Complex Hemodynamics in the Carotid Artery Bifurcation.Cardiovascular engineering and technology · 2023Article
- Recasting Current Knowledge of Human Fetal Circulation: The Importance of Computational Models.Journal of cardiovascular development and disease · 2023Review
- Transcatheter Hepatic Conduit-Azygous Vein Connection Reduces Pulmonary Arteriovenous Malformations in a Cyanotic Fontan Patient.JACC. Case reports · 2023Article
- Soft robotic patient-specific hydrodynamic model of aortic stenosis and ventricular remodeling.Science robotics · 2023Article
- In Vitro Pressure Measurements Across an Interatrial Shunt for HFpEF Treatment.Cardiovascular engineering and technology · 2022Article
- Synthesis of patient-specific multipoint 4D flow MRI data of turbulent aortic flow downstream of stenotic valves.Scientific reports · 2022Article
- Virtual Reality Cardiac Surgical Planning Software (CorFix) for Designing Patient-Specific Vascular Grafts: Development and Pilot Usability Study.JMIR cardio · 2022Article
- Impact of altered vena cava flow rates on right atrium flow characteristics.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Current state of the art in hypoplastic left heart syndrome.Frontiers in cardiovascular medicine · 2022Review
- Hemodynamic and Structural Comparison of Human Fetal Heart Development Between Normally Growing and Hypoplastic Left Heart Syndrome-Diagnosed Hearts.Frontiers in physiology · 2022Article
- Engineering Perspective on Cardiovascular Simulations of Fontan Hemodynamics: Where Do We Stand with a Look Towards Clinical Application.Cardiovascular engineering and technology · 2021Article
- Numerical Investigation of the Fetal Left Heart Hemodynamics During Gestational Stages.Frontiers in physiology · 2021Article
- 4D Flow MRI Estimation of Boundary Conditions for Patient Specific Cardiovascular Simulation.Annals of biomedical engineering · 2019Article
- Comparison of 4D Flow MRI and Particle Image Velocimetry Using an In Vitro Carotid Bifurcation Model.Annals of biomedical engineering · 2018Article
- Reduced shear stress and associated aortic deformation in the thoracic aorta of patients with chronic obstructive pulmonary disease.Journal of vascular surgery · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionAltered total cavopulmonary connection (TCPC) hemodynamics can cause long-term complications. Patient-specific anatomy hinders generalized solutions. 4D Flow MRI allows in vivo assessment, but not predictions under varying conditions and surgical approaches. Computational fluid dynamics (CFD) improves understanding and explores varying physiological conditions. This study investigated a combination of 4D Flow MRI and CFD to assess TCPC hemodynamics, accompanied with in vitro measurements as CFD validation. 4D Flow MRI was performed in extracardiac and atriopulmonary TCPC subjects. Data was processed for visualization and quantification of velocity and flow. Three-dimensional (3D) geometries were generated from angiography scans and used for CFD and a physical model construction through additive manufacturing. These models were connected to a perfusion system, circulating water through the vena cavae and exiting through the pulmonary arteries at two flow rates. Models underwent 4D Flow MRI and image processing. CFD simulated the in vitro system, applying two different inlet conditions from in vitro 4D Flow MRI measurements; no-slip was implemented at rigid walls. Velocity and flow were obtained and analyzed. The three approaches showed similar velocities, increasing proportionally with high inflow. Atriopulmonary TCPC presented higher vorticity compared to extracardiac at both inflow rates. Increased inflow balanced flow distribution in both TCPC cases. Atriopulmonary IVC flow participated in atrium recirculation, contributing to RPA outflow; at baseline, IVC flow preferentially traveled through the LPA. The combination of patient-specific in vitro and CFD allows hemodynamic parameter control, impossible in vivo. Physical models serve as CFD verification and fine-tuning tools.
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