Evidence map›Paper›PMID 25841236›Full record

ArticleThorax2015

Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life.

Debbie C P Lee, Simone A Walker, Adam J Byrne, Lisa G Gregory, James Buckley, Andrew Bush, Seif O Shaheen, Sejal Saglani, Clare M Lloyd

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thorax, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. A Single Early-Life Acetaminophen Exposure Causes Persistent Abnormalities in the Murine Lung.American journal of respiratory cell and molecular biology · 2025
    Article
  3. Review
  4. Review
  5. Long-term adverse effects of paracetamol - a review.British journal of clinical pharmacology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Debbie C P LeeLeukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, UK Immunology Programme, Centre for Life Sciences, National University of Singapore, Singapore, Singapore.
Simone A WalkerLeukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, UK.
Adam J ByrneLeukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, UK.
Lisa G GregoryLeukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, UK.
James BuckleyLeukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, UK.
Andrew BushDepartment of Respiratory Paediatrics, Royal Brompton Hospital, and National Heart and Lung Institute, Imperial College London, London, UK.
Seif O ShaheenCentre for Primary Care and Public Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, London, UK.
Sejal SaglaniLeukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, UK Department of Respiratory Paediatrics, Royal Brompton Hospital, and National Heart and Lung Institute, Imperial College London, London, UK.
Clare M LloydLeukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, UK.
Imperial College London · GBNational University of Singapore · SGQueen Mary University of London · GBRoyal Brompton Hospital · GB

Funding

Wellcome TrustWellcome Trust 087618/Z/08/Z
6 · The paper itself

Abstract

backgroundCurrent data concerning maternal paracetamol intake during pregnancy, or intake during infancy and risk of wheezing or asthma in childhood is inconclusive based on epidemiological studies. We have investigated whether there is a causal link between maternal paracetamol intake during pregnancy and lactation and the development of house dust mite (HDM) induced allergic airways disease (AAD) in offspring using a neonatal mouse model.

methodsPregnant mice were administered paracetamol or saline by oral gavage from the day of mating throughout pregnancy and/or lactation. Subsequently, their pups were exposed to intranasal HDM or saline from day 3 of life for up to 6 weeks. Assessments of airway hyper-responsiveness, inflammation and remodelling were made at weaning (3 weeks) and 6 weeks of age.

resultsMaternal paracetamol exposure either during pregnancy and/or lactation did not affect development of AAD in offspring at weaning or at 6 weeks. There were no effects of maternal paracetamol at any time point on airway remodelling or IgE levels.

conclusionsMaternal paracetamol did not enhance HDM induced AAD in offspring. Our mechanistic data do not support the hypothesis that prenatal paracetamol exposure increases the risk of childhood asthma.

Indexed as

Bronchial HyperreactivityMaternal ExposureAcetaminophenAnalgesics, Non-NarcoticAnimalsAnimals, NewbornDisease Models, AnimalFemaleMicePregnancyAcetaminophenAnalgesics, Non-NarcoticAllergic lung diseaseAsthmaPaediatric asthma

Identifiers

PMID25841236
PMCPMC4453715
OpenAlexW2125104850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.